CAJ | 학술논문

目的：考察不稳定心绞痛(UAP)患者体内血小板活化状态，探讨冠脉病变严重程度与血小板活化程度的关系。方法：UAP组55例，稳定心绞痛(SAP)组32例，均服用阿斯匹林75mg/d，对照组40例。采用流式细胞术测定活化血小板的膜蛋白CD63、CD62P、TsP的表达率。观察行冠脉造影术42例UAP患者，比较单支病变组、双支病变组和3支病变组血小板膜蛋白表达率的差异。结果：UAP组中3种膜蛋白的表达率均显著高于SAP组和对照组，男女之间无显著性差异，双支组和3支组显著高于单支组。结论：UAP患者存在高度的血小板活化状态，随冠脉病变严重程度增加而增加，小剂量阿斯匹林治疗的UAP患者仍有较高的血小板活化状态。
목적：고찰불은정심교통(UAP)환자체내혈소판활화상태，탐토관맥병변엄중정도여혈소판활화정도적관계。방법：UAP조55례，은정심교통(SAP)조32례，균복용아사필림75mg/d，대조조40례。채용류식세포술측정활화혈소판적막단백CD63、CD62P、TsP적표체솔。관찰행관맥조영술42례UAP환자，비교단지병변조、쌍지병변조화3지병변조혈소판막단백표체솔적차이。결과：UAP조중3충막단백적표체솔균현저고우SAP조화대조조，남녀지간무현저성차이，쌍지조화3지조현저고우단지조。결론：UAP환자존재고도적혈소판활화상태，수관맥병변엄중정도증가이증가，소제량아사필림치료적UAP환자잉유교고적혈소판활화상태。
Objective: To assess the platelet activation state in patients with unstable angina pectoris (UAP) and to investigate the relationship between the severity of coronary artery stenosis and platelet activation. Methods: CD63, CD62P and thrombospondin were detected using flow cytometry in 55 patients with UAP,32 with stable angina pectoris(SAP)(both given aspirin 75 mg/d) and 40 healthy controls. 42 patients with UAP underwent elective coronary arteriography. There were 10 patients with single-vessel disease,21 with double-vessel disease and 11 with three-vessel disease. Results:The three parameters in UAP group were significantly higher than in SAP and controls. There was no significant difference between male and female. Groups of double and three-vessel disease had significantly increased CD63 and thrombospondin expression comparing with single-vessel disease. Conclusion: There is elevated platelet activation in patients with UAP. Platelet activation raises with the increase of severity of coronary artery disease. Low dose oral aspirin(75mg/d) can not completely inhibit platelet activation in patients with UAP.