CAJ | 학술논문

目的探讨可溶性Fas（sFas）在Graves’病（GD）发病过程中的作用。方法应用夹心酶联免疫吸附法（ELISA），测定了68例GD患者和20例健康对照者sFas含量。结果 ①GD患者未治疗组和缓解组血清sFas水平高于健康对照组；②GD患者未治疗组和缓解组sFas.TRAb乘积高于健康对照组；③血清sFas与TRAb呈正相关关系，与游离T3、游离T4和促甲状腺素（TSH）无相关关系。结论 sFas参与了GD发病与转归的病理生理过程，可以作为GD病情监测的重要指标。
목적 탐토가용성Fas（sFas）재Graves’병（GD）발병과정중적작용。방법 응용협심매련면역흡부법（ELISA），측정료68례GD환자화20례건강대조자sFas함량。결과 ①GD환자미치료조화완해조혈청sFas수평고우건강대조조；②GD환자미치료조화완해조sFas.TRAb승적고우건강대조조；③혈청sFas여TRAb정정상관관계，여유리T3、유리T4화촉갑상선소（TSH）무상관관계。결론 sFas삼여료GD발병여전귀적병리생리과정，가이작위GD병정감측적중요지표。
Objective To investigate the concentration of soluble sFas（sFas）in Graves’disease（GD） and its clinical significance.Methods Serum levels of sFas in 68 cases of GD patients and 20 cases of healthy subjects were measured with a sandwiched ELISA method.Results ①Serum sFas levels of GD untreated group and remission group were much higher than those of healthy controls（2.08±0.82， 1.11±0.31 vs 0.70±0.5 0 ng／mL，P＜0.001）；② Multiplier of sFas.TRAb in GD untreated group and remission group were much higher than those of healthy controls（80.01±57.62， 3.34±1.69 vs 0.81±0.80，P＜0.001）；③The concentration of serum sFas was significantly correlated with anti-thyrotropin（TSH） receptor antibody titers（r＝0.309，P＜0.05），but not with other clinical parameters（free triiodothyronine，free thyroxine and TSH）（r＝0.041—0.146，P＞0.05）.Conclusion Serum sFas may play a pivotal role in the pathogenesis of GD.