铁道医学
鐵道醫學
철도의학
2000年
5期
300-302
,共3页
乳腺癌%瘤内微血管密度%增殖细胞核抗原%免疫组化%预后
乳腺癌%瘤內微血管密度%增殖細胞覈抗原%免疫組化%預後
유선암%류내미혈관밀도%증식세포핵항원%면역조화%예후
breast carcinoma%intratumoral miccrovascular density%proliferating cell nuclear antigen%immunohistochemistry%prognosis
目的 研究乳腺癌瘤内微血管密度(Intratumaral microvascular density，IMVD)和增殖细胞核抗原(Proliferatingcell nuclear antigen，PCNA)的表达及其临床病理学意义。方法 采用免疫组化SP法对80例原发性乳腺癌的IMVD和PCNA进行检测，对有随访资料的57例患者用Logistic回归进行多因素生存分析。结果 IMVD和PCNA表达都与腋窝淋巴结转移及组织学分级密切相关。IMVD和PCNA表达之间也高度相关。临床分期、腋窝淋巴结转移、IMVD和PCNA分别具有独立预后价值。结论 用IMVD和PCNA来反映乳腺癌增殖活性和估测预后，具有重要的实用价值
目的 研究乳腺癌瘤內微血管密度(Intratumaral microvascular density，IMVD)和增殖細胞覈抗原(Proliferatingcell nuclear antigen，PCNA)的錶達及其臨床病理學意義。方法 採用免疫組化SP法對80例原髮性乳腺癌的IMVD和PCNA進行檢測，對有隨訪資料的57例患者用Logistic迴歸進行多因素生存分析。結果 IMVD和PCNA錶達都與腋窩淋巴結轉移及組織學分級密切相關。IMVD和PCNA錶達之間也高度相關。臨床分期、腋窩淋巴結轉移、IMVD和PCNA分彆具有獨立預後價值。結論 用IMVD和PCNA來反映乳腺癌增殖活性和估測預後，具有重要的實用價值
목적 연구유선암류내미혈관밀도(Intratumaral microvascular density，IMVD)화증식세포핵항원(Proliferatingcell nuclear antigen，PCNA)적표체급기림상병이학의의。방법 채용면역조화SP법대80례원발성유선암적IMVD화PCNA진행검측，대유수방자료적57례환자용Logistic회귀진행다인소생존분석。결과 IMVD화PCNA표체도여액와림파결전이급조직학분급밀절상관。IMVD화PCNA표체지간야고도상관。림상분기、액와림파결전이、IMVD화PCNA분별구유독립예후개치。결론 용IMVD화PCNA래반영유선암증식활성화고측예후，구유중요적실용개치
Objective To investigate intratumaral microvascular density(lMVD) and the expression of proliferating cell nuclearantigen(PCNA) in breast carcinoma and their clinicopathologic significance. Method The IMVD and the expression of PCNA in 80 pri-mary breast carcinoma were determined by immunohistochemical SP method. The effect of common pre and post operative clinicopathologicfeature, IMVD and PCNA expression on 57 patients overal survival was tested by stepwise logistic regression. Results Both IMVD and PC-NA expression were closely correlated with axillary lymph-node metastasis and histologic grading. There was a significant positive correlationbetween IMVD and PCNA expression. The clinical stage, axillary lymph-node states,IMVD and PCNA were all independent powerful prog-nostic factors for these patients. Conclusion These findings suggest that the detections of IMVD and PCNA have considerable practicalvalue in reflecting the proliferative activity of breast carcinoma and evaluating the prognosis.
