CAJ | 학술논문

目的：探讨 p21蛋白和雌激素受体（ estrogen receptor,ER）在大肠癌中的表达及其与大肠癌临床生物学行为的关系。方法：采用免疫组织化学方法（ LSAB），对 206例大肠癌标本分别进行 p21蛋白和 ER表达的检测 ,并结合临床资料进行分析。结果：大肠癌 p21蛋白的表达与 ER的表达具有明显负相关（ r=-0.6613， P<0.01）。 p21蛋白及 ER的表达与患者年龄、性别、肿瘤部位、大体类型、组织类型、 Dukes'分期等无关（ r< 0.4， P>0.05）；与患者预后明显相关（ P<0.01），即 p21表达水平越高患者预后越差，而 ER的表达水平越高则患者预后越好。结论：大肠癌 p21蛋白的异常表达可能与雌激素代谢紊乱有关， p21蛋白和 ER表达的检测有助于大肠癌的临床诊断及预后的评估。
목적：탐토 p21단백화자격소수체（ estrogen receptor,ER）재대장암중적표체급기여대장암림상생물학행위적관계。방법：채용면역조직화학방법（ LSAB），대 206례대장암표본분별진행 p21단백화 ER표체적검측 ,병결합림상자료진행분석。결과：대장암 p21단백적표체여 ER적표체구유명현부상관（ r=-0.6613， P<0.01）。 p21단백급 ER적표체여환자년령、성별、종류부위、대체류형、조직류형、 Dukes'분기등무관（ r< 0.4， P>0.05）；여환자예후명현상관（ P<0.01），즉 p21표체수평월고환자예후월차，이 ER적표체수평월고칙환자예후월호。결론：대장암 p21단백적이상표체가능여자격소대사문란유관， p21단백화 ER표체적검측유조우대장암적림상진단급예후적평고。
Objective： This study was designed to explore the relationship between clinicobiological acting and expression of p21 protein and estrogen receptor(ER) in colorectal cancer. Methods： The intensity of expression of p21 protein and ER for 206 patients with colorectal cancers were determined by labeled-streptokinase avidin-biotin(LSAB) assay. Results： The expression of p21 protein is negatively correlated with that of ER in colorectal cancer(r=-0.6613, P<0.01). The intensity of expression of p21 protein and ER in colorectal cancers were not related with the patients age, sexuality, tumor position, pathological type, histological type, Dukes stage etc.(r< 0.4,P>0.05). Both the expressions were related to the prognosis of colorectal cancer(P<0.01). Higher the intensity of expression of p21 protein worse the patients prognosis, and higher the intensity of expression of ER better the patient s prognosis. Conclusions： The abnormal expression of p21 protein is related to the dysbolism of estrogen in colorectal cancer. The detection of p21 protein and ER are helpful for diagnosis and prognostic evaluation for colorectal cancer.