CAJ | 학술논문

目的观察亚胺培南/西司他丁对血液系统疾病并发院内感染的治疗效果。方法 52例患者，单一使用亚胺培南/西司他丁或亚胺培南/西司他丁与其他抗菌素合用。亚胺培南/西司他丁每日剂量15～2g，静脉滴注。结果 1.亚胺培南/西司他丁治疗的总有效率为59.6％；2.对G+需氧菌及G需氧菌感染的临床有效率分别为44.4％，60.0％；3.应用第三代头孢菌素无效的患者用亚胺培南/西司他丁治疗，总有效率达56.4％；4.粒细胞缺乏合并感染患者中的有效率为51.9％。结论亚胺培南/西司他丁具有高效、广谱的抗菌作用，是治疗血液系统疾病院内感染的有效药物。
목적관찰아알배남/서사타정대혈액계통질병병발원내감염적치료효과。방법 52례환자，단일사용아알배남/서사타정혹아알배남/서사타정여기타항균소합용。아알배남/서사타정매일제량15～2g，정맥적주。결과 1.아알배남/서사타정치료적총유효솔위59.6％；2.대G+수양균급G수양균감염적림상유효솔분별위44.4％，60.0％；3.응용제삼대두포균소무효적환자용아알배남/서사타정치료，총유효솔체56.4％；4.립세포결핍합병감염환자중적유효솔위51.9％。결론아알배남/서사타정구유고효、엄보적항균작용，시치료혈액계통질병원내감염적유효약물。
Objective To evaluate the clinical efficacy of imipenem/cilastatin in the treatment of nosocomial infectious complications in patients with hematological diseases. Methods 52 patients were treated with imipenem/cilastatin alone or in combination with other antibiotics. It was administered intravenously at a dosage of 1.5～2g per day. Results 1. The overall response rate of imipenem/cilastatin was 59.6％. 2. For Grme - positive and Grme - negative aerobes infections the clinical response rates were 44.4％ and 60.0％, respectively. 3. The response rate of imipenem/cilastatin in patients who failed to respond to the third generation cephalosporins was 56.4％. 4. The response rate in febrile agranulocytosis patients was 51.9％. Conclusion Imipenem/cilastatin is a highly effective and broad-spectrum antibacterial agent for the treatment of nosocomial infectious complications in patients with hematologic diseases.