CAJ | 학술논문

应用离子淌度-孔模型研究了药物物化性质与离子导入的关系。以盐酸丁卡因、盐酸普鲁卡因、盐酸达克罗宁、盐酸利多卡因和盐酸布比卡因等5种局麻药为模型药物，分别测定它们的离子淌度(u)，并采用双室扩散池法，测定它们通过离体大鼠腹部皮肤时的离子导入增渗倍数(ER)。并以logER对分子量(MW)和loguj线性回归得：logER=1.961-5.85×10-3MW+0.776loguj(r=0.9988)。按上述方程预测盐酸布比卡因的ER值，同实验结果非常接近。
응용리자창도-공모형연구료약물물화성질여리자도입적관계。이염산정잡인、염산보로잡인、염산체극라저、염산리다잡인화염산포비잡인등5충국마약위모형약물，분별측정타문적리자창도(u)，병채용쌍실확산지법，측정타문통과리체대서복부피부시적리자도입증삼배수(ER)。병이logER대분자량(MW)화loguj선성회귀득：logER=1.961-5.85×10-3MW+0.776loguj(r=0.9988)。안상술방정예측염산포비잡인적ER치，동실험결과비상접근。
The quantitative relationship between physicochemical properties and transdermal flux of drug iontophoresis was studied using an ionic mobility-pore model.Tetracaine hydrochloride,procaine hydrochloride,dyclonine hydrochloride,lidocaine hydrochloride and bupivacaine hydrochloride were used as model drugs.The enhancing rate (ER) of model drugs through rat skin in vitro was determined respectively using Valia-Chien two-chamber diffusion cell.The ionic mobilities were also examined.Linear regression of the former four drugs showed that logER=1.961-5.85×10-3MW+0.776 log u(r=0.9988).According to this equation,the calculated ER of bupivacaine hydrochloride is 14.2,it is very close to the experimental result.