CAJ | 학술논문

目的探讨中药草苁蓉提取物对AD模型大鼠学习记忆能力及神经元凋亡的影响.方法将60只健康SD大鼠随机分为正常组、假手术组、模型组和中药高、中、低剂量组.采用Aβ_(1-40)建立AD模型,中药组予以草苁蓉提取物按高、中、低3种不同剂量灌胃治疗,治疗结束后测定其学习记忆能力和神经元凋亡百分比.结果中药组大鼠学习记忆能力高于模型组(P<0.01),而神经元凋亡百分比低于模型组(P<0.01).结论中药草苁蓉提取物可有效改善AD大鼠学习记忆障碍,减少胆碱能神经元凋亡,从而起到治疗作用.
목적 탐토중약초종용제취물대AD모형대서학습기억능력급신경원조망적영향.방법 장60지건강SD대서수궤분위정상조、가수술조、모형조화중약고、중、저제량조.채용Aβ_(1-40)건립AD모형,중약조여이초종용제취물안고、중、저3충불동제량관위치료,치료결속후측정기학습기억능력화신경원조망백분비.결과 중약조대서학습기억능력고우모형조(P<0.01),이신경원조망백분비저우모형조(P<0.01).결론 중약초종용제취물가유효개선AD대서학습기억장애,감소담감능신경원조망,종이기도치료작용.
Objective To investigate the influence of Boschniakia rossica extract on learning, memory and neuronal apoptosis in AD model rats. Methods 60 healthy SD rats were randomly divided into normal group, sham group, the model group and the group of traditional Chinese medicine with high-dose, medium-dose and low-dose. To establish the AD model by Aβ_(1-40), give the traditional Chinese medicine groups were administered three different treatment doses of Boschniakia rossica extract:high, medium and low dose. After the treatment, rats learning,memory capability and the percentage of neuronal apoptosis were tested. Results The learning and memory capability in the group of traditional Chinese medicine rats is better than in the model group (P<0.01), while the hippocampus and cortex parts neuronal apoptosis percentage is lower than the model group (P<0.01). Conclusion The herb Boschniakia rossica extract to AD rats can effectively improve learning and memory obstacle,inhibit the cholinergic neuronal apoptosis.