CAJ | 학술논문

自肿瘤干细胞(CSC)学说提出以来,受到了科学界的广泛关注,也是争论的焦点问题.正确认识肿瘤干细胞的生物学特性和调控机制,寻找治愈肿瘤的新途径新方法,是目前最重要研究方向之一.本文就实体瘤中CSC的起源、分离鉴定方法,以及信号通路、微环境,小分子RNA与CSC的作用和肿瘤的靶向治疗等方面展开论述.
자종류간세포(CSC)학설제출이래,수도료과학계적엄범관주,야시쟁론적초점문제.정학인식종류간세포적생물학특성화조공궤제,심조치유종류적신도경신방법,시목전최중요연구방향지일.본문취실체류중CSC적기원、분리감정방법,이급신호통로、미배경,소분자RNA여CSC적작용화종류적파향치료등방면전개논술.
The investigation and study of cancer stem cells(CSC)have received enormous attention since the theory has been proposed,but remain topics of considerable controversy.A correct understanding of the biological characteristics of cancer stem cells and relevant mechanisms,to find new ways and methods to cure cancer are currently the most important direction.In the following text,we discuss the origin,the identification,regulatory pathway,micro-environment,the role of miRNA in the CSC and the new potential therapeutic targets elucidated by considering cancer as a problem in stem cell biology.