CAJ | 학술논문

巨噬细胞移动抑制因子(macrophage migration inhibitory factor,MIF)是一种具有多种生物活性的细胞因子,处于免疫调节的中心环节,在机体的炎症和免疫反应中起重要作用.在一些疾病中,MIF的表达水平发生改变.其启动子的两个多态位点影响其表达,并且与某些疾病的易感性、严重性及抗药性相关.本文首先介绍MIF的生物学功能,然后对近些年来MIF基因多态性与疾病易感性与严重性的研究进展作一综述.
거서세포이동억제인자(macrophage migration inhibitory factor,MIF)시일충구유다충생물활성적세포인자,처우면역조절적중심배절,재궤체적염증화면역반응중기중요작용.재일사질병중,MIF적표체수평발생개변.기계동자적량개다태위점영향기표체,병차여모사질병적역감성、엄중성급항약성상관.본문수선개소MIF적생물학공능,연후대근사년래MIF기인다태성여질병역감성여엄중성적연구진전작일종술.
Macrophage migration inhibitory factor(MIF),which is a cytokine of many biological activities,plays a key role in the immunoregulatory system.The MIF levels produced in vivo directly influence susceptibility and severity of some diseaseg.Polymorphisms exist in the promoter region of the MIF that alters its expression.In this review,we discuss the biological role of MIF,and summarize the recent findings describing the MIF promoter polymorphisms as well as its correlation with the susceptibility and severity of diseases.