CAJ | 학술논문

目的观察静脉注射左卡尼汀对维持性血液透析(MHD)患者炎症状态的影响.方法选择透析龄超过2个月的MHD患者42例,每次透析结束后,静脉注射左卡尼汀1 g,随访6个月,分别检测治疗前、治疗后1个月、治疗后6个月患者的主要血生化指标、C反应蛋白、白介素26等.结果治疗1个月后,MHD患者透析后干体重有上升;治疗6个月后,患者平均干体重较治疗前显著升高(P<0.05),血白蛋白、前白蛋白和血红蛋白较治疗前明显升高(P<0.05,P<0.01),(反应蛋白、白介素26)等平均值均较治疗前明显下降(P<0.01),血总胆固醇、三酰甘油水平治疗前后无显著差异.结论左卡尼汀可使MHD患者的炎症状态明显好转,有效改善患者的营养状态.
목적 관찰정맥주사좌잡니정대유지성혈액투석(MHD)환자염증상태적영향.방법 선택투석령초과2개월적MHD환자42례,매차투석결속후,정맥주사좌잡니정1 g,수방6개월,분별검측치료전、치료후1개월、치료후6개월환자적주요혈생화지표、C반응단백、백개소26등.결과 치료1개월후,MHD환자투석후간체중유상승;치료6개월후,환자평균간체중교치료전현저승고(P<0.05),혈백단백、전백단백화혈홍단백교치료전명현승고(P<0.05,P<0.01),(반응단백、백개소26)등평균치균교치료전명현하강(P<0.01),혈총담고순、삼선감유수평치료전후무현저차이.결론 좌잡니정가사MHD환자적염증상태명현호전,유효개선환자적영양상태.
Objective To investigate the effect oflevecamitine on nutrition,microinflammation status in ma-intenance hemodialysis (MHD) patients. Methods Forty two MHD patients were selected, who had undergone he-modialysis for at least two months before the study. One gram of levoeamitine was injecfed to the patients at the end of each dialysis treatment for six months. The parameters of inflammation stress were studied. Results After treatment with levocarnitine for six months, the average levels of dry body weight decreased markedly. ( P<0.05 ), The aver-age serum levels of C2reaetive protein (CRP),interleuldn26 (IL26) ,tumor necrosis factor2α(TNF2α), (P<0.01 ). Difference was not significant between serum lipid parameters before and after the treatment. Conclusion Intravenous supplement with levocamitine in MHD patients, appears to be associated with an improvement of nutrition and mieroinflammation status.