CAJ | 학술논문

各种类型的终末期肝病严重威胁着人类的健康.现有的常规治疗方法均不理想,原位肝移植亦因供体肝的短缺受到限制,而以肝干细胞移植为基础的新型疗法则具有光明前景.肝卵圆细胞是受损肝脏内的一种肝干/祖细胞,或称肝前体细胞.由于其细胞核呈卵圆形,核质比高等形态学特征,故而得名.经过几十年的探索,肝卵圆细胞研究已经获得了初步的成果.现在人们已将注意力逐渐转移到肝卵圆细胞激活、分化的调控机制方面,而调控机制中的信号通路又是研究的重点.肝卵圆细胞的激活和增殖过程有许多信号通路参与.Wnt/β-catenin信号通路作为Wnt信号通路的一个分支,对肝卵圆细胞的激活和增殖有重要作用,但其具体机制尚未阐明.本文就肝卵圆细胞激活和增殖过程中Wnt/β-catenin信号通路的作用做一综述.
각충류형적종말기간병엄중위협착인류적건강.현유적상규치료방법균불이상,원위간이식역인공체간적단결수도한제,이이간간세포이식위기출적신형요법칙구유광명전경.간란원세포시수손간장내적일충간간/조세포,혹칭간전체세포.유우기세포핵정란원형,핵질비고등형태학특정,고이득명.경과궤십년적탐색,간란원세포연구이경획득료초보적성과.현재인문이장주의력축점전이도간란원세포격활、분화적조공궤제방면,이조공궤제중적신호통로우시연구적중점.간란원세포적격활화증식과정유허다신호통로삼여.Wnt/β-catenin신호통로작위Wnt신호통로적일개분지,대간란원세포적격활화증식유중요작용,단기구체궤제상미천명.본문취간란원세포격활화증식과정중Wnt/β-catenin신호통로적작용주일종술.
End stage liver disease is a serious threat to human health.Existing conventional therapies are far from ideal,and orthotopic liver transplantation is limited by the lack of donor liver.A new therapy,transplantation of hepatic stem cell,is a promising approach.Hepatic oval cells are hepatic stem/progenitor cells(HSC/HPC)during hepatic regeneration,and they are being referred to as hepatic precursor cells.It got its name because of its oval nucleus,high nuclear/cytoplasmic ratio and other morphological features.Research has shown increasingly importance in the knowledge of hepatic oval cells.There are many signaling pathways in hepatic oval cells activation and proliferation.As a branch of the Wnt signaling pathway,Wnt/β-catenin signaling pathway has a significant effect on hepatic oval cells activation and proliferation.However,the exact mechanisms of this process have not been completely elucidated.This review describes the role of Wnt/β-catenin signaling pathway in hepatic oval cell activation and proliferation.