中华神经科杂志
中華神經科雜誌
중화신경과잡지
Chinese Journal of Neurology
2012年
7期
484-489
,共6页
常大川%赵忠新%包旭芳%郑良成%张鹏%张琳%李雁鹏%吴惠涓%庄建华%王文昭%贺斌
常大川%趙忠新%包旭芳%鄭良成%張鵬%張琳%李雁鵬%吳惠涓%莊建華%王文昭%賀斌
상대천%조충신%포욱방%정량성%장붕%장림%리안붕%오혜연%장건화%왕문소%하빈
睡眠剥夺%睡眠障碍,昼夜节律性%觉醒状态%认知%多道睡眠描记术
睡眠剝奪%睡眠障礙,晝夜節律性%覺醒狀態%認知%多道睡眠描記術
수면박탈%수면장애,주야절률성%각성상태%인지%다도수면묘기술
Sleep deprivation%Sleep disorders,circadian rhythm%Wakefulness%Cognition%Polysomnography
目的 研究全睡眠剥夺(30 h)后不同时长恢复性小睡的睡眠结构差异以及对随后睡眠惯性期认知能力的影响.方法 选择10名健康男性志愿者,年龄(20.8±2.1)岁,进行自身前后对照性试验研究.试验分为2个阶段,第一阶段是30 h全睡眠剥夺后进行20 min小睡(20 min小睡组),第二阶段为30 h睡眠剥夺后进行2h小睡(2h小睡组),两个阶段试验之间正常作息1周.小睡期间进行多导睡眠图(PSG)监测,观察睡眠进程及睡眠结构.分别在唤醒后5、30、50 min进行认知功能测试,包括持续注意试验、Stroop词色干扰试验、数字相加试验.结果 (1)睡眠剥夺后,两组均可见睡眠潜伏期缩短.20 min小睡组的睡眠结构主要为非快速眼球运动睡眠中的1期和2期；而与健康人睡眠结构比较,2h小睡组睡眠结构中慢波睡眠比例增加,快速眼球运动睡眠比例减少.(2)睡眠惯性对认知行为学的影响:与基线值比较,两组在不同时长恢复性小睡后睡眠惯性期均出现持续注意力、选择注意力、计算力的下降[ CPT正确反应数(次/3 min):371.8±21.3与334.4±22.4、373.2±19.0与323.7±23.8,t=10.443、7.774,均P＜0.01；Stroop词色干扰试验干扰分(分):20.3±1.5与17.3±1.0、21.5±0.8与16.1±1.4,t=8.478、4.934,均P＜0.05;数字相加试验完成时间(s):222.2±13.2与266.6±23.7、226.3±10.9与267.6±23.4,t =5.748、6.685,均P＜0.01].与20 min小睡组比较,2h小睡组虽然在睡眠惯性早期(唤醒后5 min)认知功能受损更重,但恢复更快(唤醒后30 min即完全恢复).结论 (1)青年男性在经历30 h全睡眠剥夺后不同时长的恢复性小睡,在其睡眠结构、唤醒时的睡眠分期上差异有统计学意义.(2)恢复性小睡后睡眠惯性对持续注意力、选择注意力、计算力等认知功能产生负性影响.(3)过分片段化的睡眠并不利于机体的恢复.
目的 研究全睡眠剝奪(30 h)後不同時長恢複性小睡的睡眠結構差異以及對隨後睡眠慣性期認知能力的影響.方法 選擇10名健康男性誌願者,年齡(20.8±2.1)歲,進行自身前後對照性試驗研究.試驗分為2箇階段,第一階段是30 h全睡眠剝奪後進行20 min小睡(20 min小睡組),第二階段為30 h睡眠剝奪後進行2h小睡(2h小睡組),兩箇階段試驗之間正常作息1週.小睡期間進行多導睡眠圖(PSG)鑑測,觀察睡眠進程及睡眠結構.分彆在喚醒後5、30、50 min進行認知功能測試,包括持續註意試驗、Stroop詞色榦擾試驗、數字相加試驗.結果 (1)睡眠剝奪後,兩組均可見睡眠潛伏期縮短.20 min小睡組的睡眠結構主要為非快速眼毬運動睡眠中的1期和2期；而與健康人睡眠結構比較,2h小睡組睡眠結構中慢波睡眠比例增加,快速眼毬運動睡眠比例減少.(2)睡眠慣性對認知行為學的影響:與基線值比較,兩組在不同時長恢複性小睡後睡眠慣性期均齣現持續註意力、選擇註意力、計算力的下降[ CPT正確反應數(次/3 min):371.8±21.3與334.4±22.4、373.2±19.0與323.7±23.8,t=10.443、7.774,均P＜0.01；Stroop詞色榦擾試驗榦擾分(分):20.3±1.5與17.3±1.0、21.5±0.8與16.1±1.4,t=8.478、4.934,均P＜0.05;數字相加試驗完成時間(s):222.2±13.2與266.6±23.7、226.3±10.9與267.6±23.4,t =5.748、6.685,均P＜0.01].與20 min小睡組比較,2h小睡組雖然在睡眠慣性早期(喚醒後5 min)認知功能受損更重,但恢複更快(喚醒後30 min即完全恢複).結論 (1)青年男性在經歷30 h全睡眠剝奪後不同時長的恢複性小睡,在其睡眠結構、喚醒時的睡眠分期上差異有統計學意義.(2)恢複性小睡後睡眠慣性對持續註意力、選擇註意力、計算力等認知功能產生負性影響.(3)過分片段化的睡眠併不利于機體的恢複.
목적 연구전수면박탈(30 h)후불동시장회복성소수적수면결구차이이급대수후수면관성기인지능력적영향.방법 선택10명건강남성지원자,년령(20.8±2.1)세,진행자신전후대조성시험연구.시험분위2개계단,제일계단시30 h전수면박탈후진행20 min소수(20 min소수조),제이계단위30 h수면박탈후진행2h소수(2h소수조),량개계단시험지간정상작식1주.소수기간진행다도수면도(PSG)감측,관찰수면진정급수면결구.분별재환성후5、30、50 min진행인지공능측시,포괄지속주의시험、Stroop사색간우시험、수자상가시험.결과 (1)수면박탈후,량조균가견수면잠복기축단.20 min소수조적수면결구주요위비쾌속안구운동수면중적1기화2기；이여건강인수면결구비교,2h소수조수면결구중만파수면비례증가,쾌속안구운동수면비례감소.(2)수면관성대인지행위학적영향:여기선치비교,량조재불동시장회복성소수후수면관성기균출현지속주의력、선택주의력、계산력적하강[ CPT정학반응수(차/3 min):371.8±21.3여334.4±22.4、373.2±19.0여323.7±23.8,t=10.443、7.774,균P＜0.01；Stroop사색간우시험간우분(분):20.3±1.5여17.3±1.0、21.5±0.8여16.1±1.4,t=8.478、4.934,균P＜0.05;수자상가시험완성시간(s):222.2±13.2여266.6±23.7、226.3±10.9여267.6±23.4,t =5.748、6.685,균P＜0.01].여20 min소수조비교,2h소수조수연재수면관성조기(환성후5 min)인지공능수손경중,단회복경쾌(환성후30 min즉완전회복).결론 (1)청년남성재경력30 h전수면박탈후불동시장적회복성소수,재기수면결구、환성시적수면분기상차이유통계학의의.(2)회복성소수후수면관성대지속주의력、선택주의력、계산력등인지공능산생부성영향.(3)과분편단화적수면병불리우궤체적회복.
Objective To study the effects of sleep inertia (SI) of different time course sleeps on sleep stages and cognitions in healthy men after 30 h sleep deprivation,and also to investigate the mechanism of cognitive functions impairment in sleep inertia stages and the influential factors of sleep inertia.Methods Ten healthy men (age,(20.8 ±2.1) years) participated in the program.The program was divided into 2 stages.First,participants attended a series of tests after 20 min nap(20 min nap group)after 30 h sleep deprivation.The testing series included 3 parts:the continuous performance task,the Stroop Tests,and the Addition Tests.The series of tests were done 3 times immediately after the volunteers were awoken and each lasted about 15 minutes with an interval of 10 minutes between each test.The polysomnogram (PSG) was recorded during the nap.The following 7 days was set as washing-out period to ensure a complete recovery.Participants repeated the similar processes with 2 h nap(2 h nap group) instead of 20 min nap.The cognitive performance of each group was compared with each other along with the best cognitive performance in awakening to estimate whether or not the cognitive abilities regained the normal condition.Results ( 1 ) Sleep latency became shortened in both groups after 30 h sleep deprivation.There were no slow wave sleep (SWS) and rapid eye movement sleep (REM) sleep stages in the 20 min naps,while the percentage of SWS was increased and percentage of REM declined in 2 h naps.(2)In the early of SI (5 min after awaking),cognitive tasks showed that the abilities of continuous attention,selected attention and addition ability were all impaired (continuous performance task:(371.8 ± 21.3 ) times/3 min vs (334.4 ± 22.4) times/3 min,( 373.2 ± 19.0) times/3 min vs ( 323.7 ± 23.8) times/3 min,t =10.443,7.774,both P＜0.01; Stroop tests:(20.3 ±1.5) points vs(17.3 ± 1.0) points,(21.5 ±0.8)points vs( 16.1 ± 1.4 ) points,t =8.478,4.934,both P ＜ 0.05 ; Addition Tests:( 222.2 ± 13.2 ) s vs ( 266.6 ±23.7 ) s,( 226.3 ± 10.9) s vs ( 267.6 ± 23.4 ) s,t =5.748,6.685,both P ＜ 0.01 ).The cognitive functions impairments of 2 h nap group were more severe at the initiation of sleep inertia,but regained the normal condition more quickly.Different cognitive tasks recovered at different speeds.The dispersion of SI needed 30 min.Conclusions ( 1 ) There are difference in the sleep construction and awaked sleep stage between 20 min nap and 2 h nap groups.(2) SI exerts negative influences on cognitive performances of continuous attention,selected attention and addition after sleep deprivation.Many factors may influence the dispersion of SI,including sleep debt,compensation of sleep debt and others.(3) Fragments of sleep are unfavorable to the recovery of body.
