中华整形外科杂志
中華整形外科雜誌
중화정형외과잡지
CHINESE JOURNAL OF PLASTIC SURGERY
2011年
3期
166-169
,共4页
詹明坤%谢义德%郭志辉%黄拔瑞%周亚宽%陈小松%李铭%杨育成
詹明坤%謝義德%郭誌輝%黃拔瑞%週亞寬%陳小鬆%李銘%楊育成
첨명곤%사의덕%곽지휘%황발서%주아관%진소송%리명%양육성
普萘洛尔%婴幼儿血管瘤
普萘洛爾%嬰幼兒血管瘤
보내락이%영유인혈관류
Propranolol%Infantile hemangioma
目的 初步探讨口服大剂量普萘洛尔治疗严重婴幼儿血管瘤的临床疗效和安全性.方法 2010年4月至2011年2月为56例严重的婴幼儿血管瘤患儿行口服普萘洛尔治疗,治疗前行全面的临床评估、心电图、血常规、肝功能、心肌酶和肌钙蛋白检查,治疗时口服普萘洛尔剂量逐渐增加,前3 d的剂量分别为每天1 ms/kg、1.5 mg/kg、2 mg/kg,每天按12 h 1次,分2次,喂奶后半小时服用,住院6 d,患儿无异常表现后出院;出院后每周复测心率,每个月复诊,6个月为1个治疗疗程,治疗结束时逐渐减量后停药.结果 56例患儿在服药后第2~4天就可观察到血管瘤的颜色改变.治疗后1个月复诊时观察血管瘤明显改善,瘤体体积不同程度变小、质地变软,伴有溃疡的患儿除1例溃疡扩大外其余均愈合.56例中10例血管瘤完全消退,46例明显改善;1例治疗3个月后血管瘤消退停止;3例出现不良反应:1例在治疗1个月后出现肝功能轻度异常,1例治疗过程中CKMB升高,给予继续观察,1例CK-MB、LDH、ALT、GGT持续升高,给予停药.结论 大剂量口服普萘洛尔治疗严重的婴幼儿血管瘤显效快,疗效明显,患儿耐受性好,不良反应少,可显著缩短血管瘤的病程,可能成为治疗严重婴幼儿血管瘤的首选方法.
目的 初步探討口服大劑量普萘洛爾治療嚴重嬰幼兒血管瘤的臨床療效和安全性.方法 2010年4月至2011年2月為56例嚴重的嬰幼兒血管瘤患兒行口服普萘洛爾治療,治療前行全麵的臨床評估、心電圖、血常規、肝功能、心肌酶和肌鈣蛋白檢查,治療時口服普萘洛爾劑量逐漸增加,前3 d的劑量分彆為每天1 ms/kg、1.5 mg/kg、2 mg/kg,每天按12 h 1次,分2次,餵奶後半小時服用,住院6 d,患兒無異常錶現後齣院;齣院後每週複測心率,每箇月複診,6箇月為1箇治療療程,治療結束時逐漸減量後停藥.結果 56例患兒在服藥後第2~4天就可觀察到血管瘤的顏色改變.治療後1箇月複診時觀察血管瘤明顯改善,瘤體體積不同程度變小、質地變軟,伴有潰瘍的患兒除1例潰瘍擴大外其餘均愈閤.56例中10例血管瘤完全消退,46例明顯改善;1例治療3箇月後血管瘤消退停止;3例齣現不良反應:1例在治療1箇月後齣現肝功能輕度異常,1例治療過程中CKMB升高,給予繼續觀察,1例CK-MB、LDH、ALT、GGT持續升高,給予停藥.結論 大劑量口服普萘洛爾治療嚴重的嬰幼兒血管瘤顯效快,療效明顯,患兒耐受性好,不良反應少,可顯著縮短血管瘤的病程,可能成為治療嚴重嬰幼兒血管瘤的首選方法.
목적 초보탐토구복대제량보내락이치료엄중영유인혈관류적림상료효화안전성.방법 2010년4월지2011년2월위56례엄중적영유인혈관류환인행구복보내락이치료,치료전행전면적림상평고、심전도、혈상규、간공능、심기매화기개단백검사,치료시구복보내락이제량축점증가,전3 d적제량분별위매천1 ms/kg、1.5 mg/kg、2 mg/kg,매천안12 h 1차,분2차,위내후반소시복용,주원6 d,환인무이상표현후출원;출원후매주복측심솔,매개월복진,6개월위1개치료료정,치료결속시축점감량후정약.결과 56례환인재복약후제2~4천취가관찰도혈관류적안색개변.치료후1개월복진시관찰혈관류명현개선,류체체적불동정도변소、질지변연,반유궤양적환인제1례궤양확대외기여균유합.56례중10례혈관류완전소퇴,46례명현개선;1례치료3개월후혈관류소퇴정지;3례출현불량반응:1례재치료1개월후출현간공능경도이상,1례치료과정중CKMB승고,급여계속관찰,1례CK-MB、LDH、ALT、GGT지속승고,급여정약.결론 대제량구복보내락이치료엄중적영유인혈관류현효쾌,료효명현,환인내수성호,불량반응소,가현저축단혈관류적병정,가능성위치료엄중영유인혈관류적수선방법.
Objective To investigate the clinical results of the treatment of severe infantile hemangioma with high-dose propranolol in Chinese. Methods 56 cases with severe infantile hemangioma were treated with propranolol. Clinical evaluation, electrocardiography, and experimental examination of liver function and heart function were performed before treatment. The daily dose of propranolol was increased from 1 mg/kg at the first day to 1. 5 mg/kg at the second day, and to 2 mg/kg at the third day.The propranolol was given twice a day. The treatment was lasted for six months. The patients were visited every month. Results The lesion color was changed after 2-4 days of treatment in all the cases. All the lesions were dramatically improved after one month of treatment. The ulceration were healed, except one case. Until now, complete regression was achieved in 10 cases and marked improvement in 46 cases. Side effects were happened in 3 cases, including one case of abnormal liver function, one case of CK-MB increase and one case of continuous increase of CK-MB, LDH, ALT, GGT. Conclusions High-dose Propranolol is very effective in the treatment of infantile hemangioma with minor side effects and short disease period. It might be used as the first-line treatment for infantile hemangioma.