CAJ | 학술논문

目的探讨经鼻持续气道正压通气(NCPAP)在治疗早产儿早期肺透明膜病的治疗效果及安全性.方法对早产儿早期肺透明膜病经头罩吸氧下临床表现和低氧血症未改善者共28例采用NCPAP治疗.观察NCPAP治疗前后的临床表现和动脉血气分析变化.结果应用NCPAP治疗6 h后,24 h后动脉血气氧分压,经皮血氧饱和度较治疗前上升,两者比较差异具统计学意义(P<0.05);治疗6h后,24 h后动脉血气二氧化碳分压.呼吸频率较治疗前降低,两者比较差异具有统计学意义(P<0.05).本组有效22例,无效6例,总有效率78.58%.28例治疗过程中未发现气胸,鼻粘膜糜烂、感染等并发症.结论 NCPAP治疗早产儿早期肺透明膜病安全用效,值得基层医院推广应用.
목적 탐토경비지속기도정압통기(NCPAP)재치료조산인조기폐투명막병적치료효과급안전성.방법 대조산인조기폐투명막병경두조흡양하림상표현화저양혈증미개선자공28례채용NCPAP치료.관찰NCPAP치료전후적림상표현화동맥혈기분석변화.결과 응용NCPAP치료6 h후,24 h후동맥혈기양분압,경피혈양포화도교치료전상승,량자비교차이구통계학의의(P<0.05);치료6h후,24 h후동맥혈기이양화탄분압.호흡빈솔교치료전강저,량자비교차이구유통계학의의(P<0.05).본조유효22례,무효6례,총유효솔78.58%.28례치료과정중미발현기흉,비점막미란、감염등병발증.결론 NCPAP치료조산인조기폐투명막병안전용효,치득기층의원추엄응용.
Objective To invesgate the effcets and safety about nasal continuous positive airway pressure (NCPAP) on treatment of premature infants with hyaline membrane disease. Methods 28 premature infants with hyaline membrane diseases whose clinical manifestation and hypoxemia did not improved by oxygen supply from head nets were selected to be treated by NCPAP. The clinical manifestations and the changes of arterial blood gas analysis were observed before and after treatments. Results The oxygen partial pressure of arterial blood gas im-proved in 6 hours and 24 hours after treatment compared with those before treatment, so there were significant differences between two groups (P < 0.05). The carbon dioxide partial pressure of arterial blood gas and the respiratory frequency cutted down in 6 hours and 24 hours after treatment compared with those before treatment, so there were significant differences between two groups (P< 0.05). There were 22 cases with efficient effects and 6 cases with inefficient effects. No case was found to be with the complications of pneumothorax, nasal mucosal erosion and infection. Conclusion The NCPAP is safe in the treatment on premature infants with hyaline membrane disease, which deserves applica-tion in local hospitals.