循证医学
循證醫學
순증의학
THE JOURNAL OF EVIDENCE-BASED MEDICINE
2010年
1期
35-38
,共4页
流行性腮腺炎%疫苗%模糊数学%Meta分析%病例系列研究
流行性腮腺炎%疫苗%模糊數學%Meta分析%病例繫列研究
류행성시선염%역묘%모호수학%Meta분석%병례계렬연구
mumps%vaccine%fuzzy mathematics%meta-analysis%case series
目的 评价S_(79)株腮腺炎减毒活疫苗在人群中的血清抗体阳转效果.方法 通过文献检索收集1994-2008年国内外S_(79)株腮腺炎疫苗血清阳转的流行病学现场试验文献,经质量评估最终13篇入选,用模糊数学Meta分析及病例系列研究综合方法进行评价.结果 0～4岁儿童接种疫苗3年后综合效果相对值为1.18,0～13岁儿童接种S_(79)疫苗2个月内的血清阳转率为54.3%～86.4%.结论 接种1剂S_(79)疫苗3年后仍有一定的保护性抗体,不同年龄段儿童对1剂S_(79)株腮腺炎减毒活疫苗短期内有相近的抗体反应.
目的 評價S_(79)株腮腺炎減毒活疫苗在人群中的血清抗體暘轉效果.方法 通過文獻檢索收集1994-2008年國內外S_(79)株腮腺炎疫苗血清暘轉的流行病學現場試驗文獻,經質量評估最終13篇入選,用模糊數學Meta分析及病例繫列研究綜閤方法進行評價.結果 0～4歲兒童接種疫苗3年後綜閤效果相對值為1.18,0～13歲兒童接種S_(79)疫苗2箇月內的血清暘轉率為54.3%～86.4%.結論 接種1劑S_(79)疫苗3年後仍有一定的保護性抗體,不同年齡段兒童對1劑S_(79)株腮腺炎減毒活疫苗短期內有相近的抗體反應.
목적 평개S_(79)주시선염감독활역묘재인군중적혈청항체양전효과.방법 통과문헌검색수집1994-2008년국내외S_(79)주시선염역묘혈청양전적류행병학현장시험문헌,경질량평고최종13편입선,용모호수학Meta분석급병례계렬연구종합방법진행평개.결과 0～4세인동접충역묘3년후종합효과상대치위1.18,0～13세인동접충S_(79)역묘2개월내적혈청양전솔위54.3%～86.4%.결론 접충1제S_(79)역묘3년후잉유일정적보호성항체,불동년령단인동대1제S_(79)주시선염감독활역묘단기내유상근적항체반응.
Objective To evaluate population's immunogenicity to live attenuated S_(79) mumps vaccine. Methods literatures of S_(79) mumps vaccine epidemiological field trials during 1994 to 2008 were reviewed and 13 trials were enrolled. Methods of fuzzy mathematical meta analysis and case series analysis were used. Results The final relative effect (M) of 1.18 was got in the fourth year after vaccination among children of 0 to 4 years old. Seroconversion rate ranged from 54.3% to 86.4% in the first two months after vaccination among children of 0 to 13 years old. Conclusion Protective effect is seen in the fourth year after vaccination and children with different birth years have similar immunogenicity to S_(79) vaccine.
