CAJ | 학술논문

目的:美沙拉嗪和糖皮质激素是治疗溃疡性结肠炎的常用药物,本文的目的是通过研究单独使用美沙拉嗪或联合糖皮质激素治疗溃疡性结肠炎的临床对照研究.方法:通过研究2003～2008年郑州大学第二附属医院的68例溃疡性结肠炎轻度-中度患者,随机分为两组.每组患者为34例,平均年龄分别为47.10,44.12岁.其中一组患者单独使用美沙拉嗪3 g/d,Tid,4 w;另一组患者使用美沙拉嗪3 g/d,Tid和糖皮质激素(氢化考的松200 mg,i.v.gtt 3～7 d后,改为口服的泼尼松30 mg/d),4 w.治疗前后通过Truelove and Witts病理诊断和分级参照标准进行临床治疗评估.结果:68名患者用药4 w后,单独使用美沙拉嗪的34例患者有70.58%得到了完全缓解;另外使用美沙拉嚷和糖皮质激素的34例患者有88.23%完全缓解.通过临床试验发现美沙拉嗪联合糖皮质激素组缓解率明显高于单独使用美沙拉嗪组(P＜0.05);并且明显减少了脓血便次数(P＜0.05).结论:通过美沙拉嗪和糖皮质激素联合应用更有效的提高溃疡性结肠炎活动期缓解率,减少临床症状.
목적:미사랍진화당피질격소시치료궤양성결장염적상용약물,본문적목적시통과연구단독사용미사랍진혹연합당피질격소치료궤양성결장염적림상대조연구.방법:통과연구2003～2008년정주대학제이부속의원적68례궤양성결장염경도-중도환자,수궤분위량조.매조환자위34례,평균년령분별위47.10,44.12세.기중일조환자단독사용미사랍진3 g/d,Tid,4 w;령일조환자사용미사랍진3 g/d,Tid화당피질격소(경화고적송200 mg,i.v.gtt 3～7 d후,개위구복적발니송30 mg/d),4 w.치료전후통과Truelove and Witts병리진단화분급삼조표준진행림상치료평고.결과:68명환자용약4 w후,단독사용미사랍진적34례환자유70.58%득도료완전완해;령외사용미사랍양화당피질격소적34례환자유88.23%완전완해.통과림상시험발현미사랍진연합당피질격소조완해솔명현고우단독사용미사랍진조(P＜0.05);병차명현감소료농혈편차수(P＜0.05).결론:통과미사랍진화당피질격소연합응용경유효적제고궤양성결장염활동기완해솔,감소림상증상.
Objective:Mesalazine and steroid are useful in the maintenance treatment of ulcerative colitis (UC).The aim of this study was to assess and to compare the efficacy of mesalazine alone and in combination with steroid in the treatment of UC patients.Methods:A retrospective study of 68 patients admitted between March 2003 and December 2008 was done with a mild to moderate clinical flare-up of UC verified with colonoscopy.All patients were divided into two groups based on treatment received.One group including 34 (mean age 47.10 years) patients treated with mesalazine alone 1 gm three times a day for 4 weeks during maintenance treatment and another group including 34 (mean age 44.12 years) patients treated with combination therapy of mesalazine and steroid.Before and after treatment,Truelove and Witts index was calculated to access the clinical response.Results:Of the 68 patients who completed the study,70.58% of mesalazine alone and 88.23% of combination treatment attained clinical remission.Mesalazine with steroid patients experienced more symptoms free period than mesalazine alone during four weeks treatment (P＜0.05).Those patients treated with mesalazine with steroid result in less blood and mucus on their stools(P＜0.05).Conclusion:Combination therapy is more effective in the treatment of mild to moderately active UC,with significantly improving clinical response than mesalazine alone.