CAJ | 학술논문

支气管哮喘是一种慢性炎症性气道疾病,以往认为辅助性T细胞1 (Th1) /Th2比例失衡是哮喘发病的重要机制.近年发现了一种以产生IL-17为主要细胞因子的Th17细胞,在哮喘的发病机制中具有重要作用,IL-17还具有对哮喘的负性调节作用,有可能成为治疗哮喘的有意义的靶目标.
지기관효천시일충만성염증성기도질병,이왕인위보조성T세포1 (Th1) /Th2비례실형시효천발병적중요궤제.근년발현료일충이산생IL-17위주요세포인자적Th17세포,재효천적발병궤제중구유중요작용,IL-17환구유대효천적부성조절작용,유가능성위치료효천적유의의적파목표.
Bronchial asthma is a chronic inflammation airway disease.The imbalance of T helper cell (Th) 1/Th2 immunity plays an important role in the pathogenesis of allergic asthma.Recent years a new T cell lineage has been recognized as Thl7 cells because they can produce cytokines interleukin-17.The new studies find that interleukin-17 is a negative regulator of asthma,and interleukin-17 or Th17 cells may represent an interesting therapeutic target in asthma.