CAJ | 학술논문

目的探讨吸人伊洛前列素(万他维)对先天性心脏病(先心病)并肺动脉高压患儿心功能的影响.方法选择一组先心病患儿术前用口含器或面罩吸入万他维,剂量为25～30 ng·kg-1·min-1,以2 ml0.9%氯化钠溶液稀释后,通过PARI Junior BOY N压缩机压缩雾化吸入,每3小时给药一次,吸入60 min、120 min、180 min后采用连续多普勒超声波技术,测量左右心每搏心排量等血流动力学参数变化.结果在用药前和后60 min、120 min、180 min,除血流动力学有明显变化,还发现用药后左、右心排血量增加,用药后再行手术的患儿,呼吸机带管时间缩短,术后恢复顺利.结论吸人伊洛前列素可以增加心输出量,改善心功能,提示该方法治疗先心病并肺动脉高压有效可行.
목적 탐토흡인이락전렬소(만타유)대선천성심장병(선심병)병폐동맥고압환인심공능적영향.방법 선택일조선심병환인술전용구함기혹면조흡입만타유,제량위25～30 ng·kg-1·min-1,이2 ml0.9%록화납용액희석후,통과PARI Junior BOY N압축궤압축무화흡입,매3소시급약일차,흡입60 min、120 min、180 min후채용련속다보륵초성파기술,측량좌우심매박심배량등혈류동역학삼수변화.결과 재용약전화후60 min、120 min、180 min,제혈류동역학유명현변화,환발현용약후좌、우심배혈량증가,용약후재행수술적환인,호흡궤대관시간축단,술후회복순리.결론 흡인이락전렬소가이증가심수출량,개선심공능,제시해방법치료선심병병폐동맥고압유효가행.
Objective To explore the effect of inhaled iloprost (Ventavis) for patients with congenital heart disease associated with pulmonary hypertension.Methods Twenty-two patients with congenital heart disease associated with pulmonary hypertension were selected to inhale Ventsvis by atomizer before surgery ,the required dosage is 25-30ng/(kg.min),aerosolization of iloprest was inhaled by PARI Junior BOY N after diluted with 2ml physiological saline at 3-hour intervals .The change of hemodynamic effects was measured by Doppler ultrasonography after 60min,120min,and 180min.Results The left and fight vemfieular cardiac output at 60min,120min and 180rain after therapy were markedly higher than that before inhaled iloprost ,respirator therapy time was shorter in patients inhaled iloprost.Conclusion inhaled iloprost can increase cardiac output and improve patients cardiac function.Thus,the therapy with inhaled iloprost is effective and feasible.