CAJ | 학술논문

目的应用血管回声跟踪技术定量检测系统性红斑狼疮(SLE)患者颈动脉弹性功能改变情况,探讨该技术在早期诊断SLE动脉粥样硬化方而的临床价值.方法根据病程将50例SLE患者分为SLEI组(病史≤1年)和SLE2组(病史>1年),分别对SLE1组、SLE2组和25名健康对照组,应用血管回声跟踪技术检测双侧颈总动脉的压力应变弹性系数(Ep)、硬度指数(β)、顺应性(AC)、增大指数(AI)、脉搏波传导速度(PWVβ)及内-中膜厚度(IMT).结果 3组颈动脉弹性指标比较,表现为各组间AI差异无统计学意义(P>0.05),SLE1组、SLE2组较对照组右侧颈总动脉Ep、β、PWVβ指数增高[SLE1组、SLE2组、对照组右侧颈总动脉的Ep值分别为(69±20)、(103±40)、(48±18)kPa;β值分别为5.2±1.9、8.0±3.1,4.2±1.3;PWVβ值分别为5.2±0.7、6.3±1.1、4.5±0.7,AC指数降低(SLE1组、SLE2组、对照组右侧颈总动脉的AC值分别为(1.1±0.3)、(0.8±0.3)、(1.2±0.6)mm2/kPa],差异有统计学意义(P<0.01);SLE2组较SLE1组ED、β、PWVβ指数增高,AC指数降低,差异有统计学意义(P<0.01).结论应用血管回声跟踪技术可诊断早期动脉粥样硬化并定量化,为早期诊断SLE心血管并发症提供依据,具有较高的临床价值.
목적 응용혈관회성근종기술정량검측계통성홍반랑창(SLE)환자경동맥탄성공능개변정황,탐토해기술재조기진단SLE동맥죽양경화방이적림상개치.방법 근거병정장50례SLE환자분위SLEI조(병사≤1년)화SLE2조(병사>1년),분별대SLE1조、SLE2조화25명건강대조조,응용혈관회성근종기술검측쌍측경총동맥적압력응변탄성계수(Ep)、경도지수(β)、순응성(AC)、증대지수(AI)、맥박파전도속도(PWVβ)급내-중막후도(IMT).결과 3조경동맥탄성지표비교,표현위각조간AI차이무통계학의의(P>0.05),SLE1조、SLE2조교대조조우측경총동맥Ep、β、PWVβ지수증고[SLE1조、SLE2조、대조조우측경총동맥적Ep치분별위(69±20)、(103±40)、(48±18)kPa;β치분별위5.2±1.9、8.0±3.1,4.2±1.3;PWVβ치분별위5.2±0.7、6.3±1.1、4.5±0.7,AC지수강저(SLE1조、SLE2조、대조조우측경총동맥적AC치분별위(1.1±0.3)、(0.8±0.3)、(1.2±0.6)mm2/kPa],차이유통계학의의(P<0.01);SLE2조교SLE1조ED、β、PWVβ지수증고,AC지수강저,차이유통계학의의(P<0.01).결론 응용혈관회성근종기술가진단조기동맥죽양경화병정양화,위조기진단SLE심혈관병발증제공의거,구유교고적림상개치.
Objective To explore the clinical value of early diagnosis of atherosclerosis in patients with systemic lupus erythematosus (SLE) using vascular echo-tracking technique and to detect changes of elastieity of carotid artery quantitatively in SLE patients.Methods Fifry patients with SLE were divided into SLE1 group(duration≤1 year),and SLE2 group(duration>1 year)based on different course.An ultrasonic echo-tracking method was used to measure patients'pressure strain elastic modulus (Ep),the stiffness constant(β),arterial compliance(AC),augmentation index(AI),pulse wave velocity (PWVβ) and intimamedia thickness(IMT)of the common carotid arteries in 50 patients with SLE and in 25 healthy control subjects.Results Among carotid artery elasticity indicators of three groups,there was no significant difference in AI(P>0.05).Ep,β,PWVβ parameters of SLE1 group and SLE2 group were statistically higher than that of the control group[Ep of SLE1 group,SLE2 group,control group was (69±20),(103±40),(48±18)kPa respectively;β was 5.2±1.9,8.0±3.1,4.2±1.3 respectively;PWVβ was 5.2±0.7,6.3±1.1,4.5±0.7]respectively,but AC(AC of SLE1 group,SLE2 group,control group was(1.1±0.3),(0.8±0.3),(1.2±0.6)mm2/k respectively]lower than the controls(P<0.01).Ep,β,PWVβ in SLE2 group was significantly increased compared with SLE1 group,but AC was decreased (P<0.01).Conclusion The application of echo-tracking technology can be used to diagnose early atherosclerosis.Complications of cardiovascular disease in SLE have high clinical value.