国际流行病学传染病学杂志
國際流行病學傳染病學雜誌
국제류행병학전염병학잡지
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY AND INFECTIOUS DISEASE
2009年
1期
42-45
,共4页
HIV%急性感染%样本集合%RT-PCR%P24抗原
HIV%急性感染%樣本集閤%RT-PCR%P24抗原
HIV%급성감염%양본집합%RT-PCR%P24항원
HIV%Acute infection%Sample pooling%RT-PCR%P24 antigen
艾滋病已成为世界范围内重要的公共卫生问题.既往发现HIV感染者的方法主要是基于对l-IV抗体的检测,然而,在HIV感染至抗体检测阳性这一急性HIV感染(AHI)阶段,患者体内具有一过性的高病毒血症,传染性极强.开展AHI的筛查,及时发现AHI者并给予有效的干预和治疗可以防止HIV的进一步传播.减缓感染者的病程,具有个体临床和群体公共卫生的双重意义.此文综述了AHI的概念、临床表现、流行病学意义以及相应的检测技术进展和费用等.
艾滋病已成為世界範圍內重要的公共衛生問題.既往髮現HIV感染者的方法主要是基于對l-IV抗體的檢測,然而,在HIV感染至抗體檢測暘性這一急性HIV感染(AHI)階段,患者體內具有一過性的高病毒血癥,傳染性極彊.開展AHI的篩查,及時髮現AHI者併給予有效的榦預和治療可以防止HIV的進一步傳播.減緩感染者的病程,具有箇體臨床和群體公共衛生的雙重意義.此文綜述瞭AHI的概唸、臨床錶現、流行病學意義以及相應的檢測技術進展和費用等.
애자병이성위세계범위내중요적공공위생문제.기왕발현HIV감염자적방법주요시기우대l-IV항체적검측,연이,재HIV감염지항체검측양성저일급성HIV감염(AHI)계단,환자체내구유일과성적고병독혈증,전염성겁강.개전AHI적사사,급시발현AHI자병급여유효적간예화치료가이방지HIV적진일보전파.감완감염자적병정,구유개체림상화군체공공위생적쌍중의의.차문종술료AHI적개념、림상표현、류행병학의의이급상응적검측기술진전화비용등.
HIV/AIDS has become an important public health problem throughout the world. HIV insfection is usually detected through a positive antibody test. However, during the period of time between initial infection and the antibody test to register a positive result, an individual may be highly infectious in a high level of virusemia. This period, known as acute HIV infection (AHI), necessitates a different mode of HIV screening in order to improve detection, treatment and reduce HIV transmission. There is clinical and public health significance. In the current review, the concept, clinical manifestation and epidemiological significance of AHI as well as advances in early detection during this period is introduced.
