中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2009年
5期
421-423
,共3页
抗精神病药物%代谢综合征%心血管病%QT间期
抗精神病藥物%代謝綜閤徵%心血管病%QT間期
항정신병약물%대사종합정%심혈관병%QT간기
Antipsychotics%Metabolic Sydrome%Cardiovascular disease%QT interval
目的 探讨抗精神病药物致代谢综合征(metabolic syndrome,MS)及其组分与心电图QT间期的关系.方法 对460例服用抗精神病药物的精神分裂症患者进行流行病学调查、身体测量、血生化指标测定及MS诊断,记录标准12导联心电图,用Bazett公式计算校正的QT间期(QTC).采用稳态模式评估法计算胰岛素抵抗指数(HOMA-IR).结果 抗精神病药物致代谢综合征人群心电图QT间期延长者124例,占27.0%,男女心电图QT间期延长检出率分别为21.7%、32.7%,差异有显著性(χ2=7.13,P<0.01).MS、HOMA-IR、中心性肥胖、高血压、高血糖、高TG、低HDL-C的检出率分别为39.3%,38.7%,35.4%,34.1%,31.3%,29.8%,27.0%.心电图QT间期延长与中心性肥胖、高血糖、高TG、胰岛素抵抗(IR)、MS及异常组分聚集有相关关系(χ2=4.95～13.63,P<0.05).结论 心电图QT间期延长与抗精神病药物所致多项代谢异常组分、代谢异常聚集及代谢综合征相关联.
目的 探討抗精神病藥物緻代謝綜閤徵(metabolic syndrome,MS)及其組分與心電圖QT間期的關繫.方法 對460例服用抗精神病藥物的精神分裂癥患者進行流行病學調查、身體測量、血生化指標測定及MS診斷,記錄標準12導聯心電圖,用Bazett公式計算校正的QT間期(QTC).採用穩態模式評估法計算胰島素牴抗指數(HOMA-IR).結果 抗精神病藥物緻代謝綜閤徵人群心電圖QT間期延長者124例,佔27.0%,男女心電圖QT間期延長檢齣率分彆為21.7%、32.7%,差異有顯著性(χ2=7.13,P<0.01).MS、HOMA-IR、中心性肥胖、高血壓、高血糖、高TG、低HDL-C的檢齣率分彆為39.3%,38.7%,35.4%,34.1%,31.3%,29.8%,27.0%.心電圖QT間期延長與中心性肥胖、高血糖、高TG、胰島素牴抗(IR)、MS及異常組分聚集有相關關繫(χ2=4.95～13.63,P<0.05).結論 心電圖QT間期延長與抗精神病藥物所緻多項代謝異常組分、代謝異常聚集及代謝綜閤徵相關聯.
목적 탐토항정신병약물치대사종합정(metabolic syndrome,MS)급기조분여심전도QT간기적관계.방법 대460례복용항정신병약물적정신분렬증환자진행류행병학조사、신체측량、혈생화지표측정급MS진단,기록표준12도련심전도,용Bazett공식계산교정적QT간기(QTC).채용은태모식평고법계산이도소저항지수(HOMA-IR).결과 항정신병약물치대사종합정인군심전도QT간기연장자124례,점27.0%,남녀심전도QT간기연장검출솔분별위21.7%、32.7%,차이유현저성(χ2=7.13,P<0.01).MS、HOMA-IR、중심성비반、고혈압、고혈당、고TG、저HDL-C적검출솔분별위39.3%,38.7%,35.4%,34.1%,31.3%,29.8%,27.0%.심전도QT간기연장여중심성비반、고혈당、고TG、이도소저항(IR)、MS급이상조분취집유상관관계(χ2=4.95～13.63,P<0.05).결론 심전도QT간기연장여항정신병약물소치다항대사이상조분、대사이상취집급대사종합정상관련.
Objective To study the relationship between QT interval and the compements of antipsychotic-induced metabolic syndrome in schizophrenic patients. Methods Totally 460 schizophrenic patients(240 men and 220 women)aged 19～60 from the study cohort of the schizophrenic patients in treatment with antipsychotant were recruited in the study for epidemiologic examinations,involving anthropometry and measurements of blood pressure,fasting ang 2hr plasma levels of glucose and insulin and serum levels of lipid.A standard 12-lead ECG was recorded and the corrected QT (QTc)was calculated accordingly by Bazett formula.HOMA-IR index was calculated for estimating individual insulin resistance.Metabolic syndrome(MS)was diagnosed according to the definition issued by the International Diabetes Federation(IDF)in 2005.Results The prolonged QT interval was found in 124 of the 460 cases(27.0%),and the rates of prolonged QT interval being 21.7% and 32.7% in men and women respectively (χ2=7.13,P<0.01).The prevalences of MS,IR,central obesity,IFG,higher serum level of triglyceride(TG)and lower serum level of high-density lipoprotein cholesterol(HDL-C) were 39.3%,38.7%,35.4%,34.1%,31.3%,29.8% and 27.0% in schizophrenic patients population respectively.The prolonged QT interval was significantly associated with MS,IR,IFG,higher serum level of triglyceride(TG)and central obesity respectively(χ2=4.95～13.63,P<0.05).Conclusion The prolonged QT interval was significantly correlated with antipsychotic-induced metabolic syndrome(MS) and components of abnormal metabolism.
