CAJ | 학술논문

目的了解可诱导型克林霉素耐药的葡萄球菌的耐药状况及发生率.方法用常规的方法对2005年1月至2007年12月临床各种标本进行培养及分离,Vitek-2全自动微生物鉴定仪进行鉴定及药物的敏感性试验检测,诱导型克林霉素耐药采用双纸片法进行检测.结果 750株葡萄球菌中可诱导型克林霉素耐药的葡萄球菌有92株,占12.3%,387株金黄色葡萄球菌中有321株为红霉素耐药,其中235株为持续型克林霉素耐药,34株为可诱导型克林霉素耐药,占8.8%(34/387);363株凝固酶阴性葡萄球菌中有294株为红霉素耐药,其中224株为持续性耐药,58株为可诱导型克林霉素耐药,占16.0%(58/363).92株可诱导型克林霉素耐药的葡萄球菌对万古霉素、替考拉宁、磷霉素、喹努普汀/达福普汀、褐霉素及利奈唑烷均敏感,对其他抗生素存在不同程度耐药.结论临床微生物实验室应加强可诱导克林霉素耐药的检测,以指导临床合理使用林可霉素类抗生素.
목적 료해가유도형극림매소내약적포도구균적내약상황급발생솔.방법 용상규적방법대2005년1월지2007년12월림상각충표본진행배양급분리,Vitek-2전자동미생물감정의진행감정급약물적민감성시험검측,유도형극림매소내약채용쌍지편법진행검측.결과 750주포도구균중가유도형극림매소내약적포도구균유92주,점12.3%,387주금황색포도구균중유321주위홍매소내약,기중235주위지속형극림매소내약,34주위가유도형극림매소내약,점8.8%(34/387);363주응고매음성포도구균중유294주위홍매소내약,기중224주위지속성내약,58주위가유도형극림매소내약,점16.0%(58/363).92주가유도형극림매소내약적포도구균대만고매소、체고랍저、린매소、규노보정/체복보정、갈매소급리내서완균민감,대기타항생소존재불동정도내약.결론 림상미생물실험실응가강가유도극림매소내약적검측,이지도림상합리사용림가매소류항생소.
Objective To investigate the resistance of Staphyloccns with inducible clindamycin resistance,and the prevalence of inducible clindamycin resistance.Methods 750 strains Staphyloceus were collected from Jan 2005 to Dec 2007.Identification of the bacteria and antibiotics susceptibility were performed on VITEK2 all-automatic microbiology analysis system.Inducible clindamyein resistance was detected by double disk diffusion method.Results The rate of inducible clindamycin resistance in Staphyloccus was 12.3% (92/750).Of 321 Eerythromyein resistant S.aurens,235 demonstrated constitutive resistance to clindamycin,while 34 showed inducible resistance.Of 363 erythromycin resistant CNS isolates,224 demonstrated constitutive resistance to clindamycin,while 58 had inducible resistance,vancomycin、Teicoplanin,Fusidic AeidL,Quinu/Dalfopristin、Linezolid and Fosfomycin were the most active against Staphylococci in virvo.Conclusion The detection of inducible clindamycin resistance must be stressed in clinical microbiology laboratory to provide good support for reasonable antibiotic therapy.