CAJ | 학술논문

目的探讨ApoAⅠ-75 Msp1、ApoB-Msp1、ApoCⅢ-Sst1、LRP5、ApoE基因多态性与乙型肝炎血清标志物不同模式之间的内在相关性.方法将乙型肝炎血清标志物不同模式分为9组,每组80人,共720人份,采用SnaPshot法检测上述基因的多态性,最后用测序法佐证检测结果的准确性.结果 ApoAⅠ-75 Msp1、ApoE基因在乙型肝炎血清标志物不同模式之间差异有统计学意义(P＜0.05),ApoCⅢ-Sst1、ApoB-Msp1、LRP5基因则差异无统计学意义(P＞0.05).结论 ApoAⅠ-75Msp1、ApoE基因多态性与乙型肝炎血清标志物不同模式有相关性,ApoCⅢ-Sst1、ApoB-Msp1、LRP5与乙型肝炎血清标志物不同模式无相关性.
목적 탐토ApoAⅠ-75 Msp1、ApoB-Msp1、ApoCⅢ-Sst1、LRP5、ApoE기인다태성여을형간염혈청표지물불동모식지간적내재상관성.방법 장을형간염혈청표지물불동모식분위9조,매조80인,공720인빈,채용SnaPshot법검측상술기인적다태성,최후용측서법좌증검측결과적준학성.결과 ApoAⅠ-75 Msp1、ApoE기인재을형간염혈청표지물불동모식지간차이유통계학의의(P＜0.05),ApoCⅢ-Sst1、ApoB-Msp1、LRP5기인칙차이무통계학의의(P＞0.05).결론 ApoAⅠ-75Msp1、ApoE기인다태성여을형간염혈청표지물불동모식유상관성,ApoCⅢ-Sst1、ApoB-Msp1、LRP5여을형간염혈청표지물불동모식무상관성.
Objective To explore the gene polymorphisms of ApoAⅠ-75 Msp1,ApoB Msp1,ApoCⅢSst1,LRP5,and ApoE genotypes in two pairs of semi different modes of hepatitis B for HBV markers.Methods The patients are divided into 9 groups.There were a total of 720 cases,80 patients in each group,The patients was carried out by SnaPshot method (single-base multilocus micro-sequencing),and different genotypes of each locus were conducted by the method of sequencing in order to support the final evidence of the accuracy of test results. Results There was association between gene polymorphisms of ApoAⅠ-75Msp1 and ApoE and different modes of two pairs of semi-hepatitis B ( P ＜ 0.05 ),while there wasn't any association between gene polymorphisms of ApoB-Msp1,ApoCⅢ-Sst1, LRP5 and different modes of two pairs of semi-hepatitis B (P ＞ 0.05 ).Conclusion The gene polymorphism of ApoAⅠ-75Msp1 and ApoE was associated with the different modes of HBV markers.