中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2011年
14期
3-5
,共3页
化疗灌注及栓塞%晚期卵巢上皮性癌%组织多肽特异抗原%癌抗原125
化療灌註及栓塞%晚期卵巢上皮性癌%組織多肽特異抗原%癌抗原125
화료관주급전새%만기란소상피성암%조직다태특이항원%암항원125
Interventional chemotherapy infusion and embolism%Advanced stage epithelial ovarian cancer%Tissue polypeptide specific antigen%CA125
目的 探讨晚期卵巢上皮性癌患者动脉化疗灌注及栓塞治疗前后血浆组织多肽特异抗原(TPS)、癌抗原125(CA125)的表达变化,进而评估晚期卵巢上皮性癌患者介入治疗的疗效及应用价值.方法 对25例晚期卵巢上皮性癌患者术前行髂内动脉、卵巢动脉化疗灌注及栓塞,采用ELISA和EIA法检测患者介入治疗前后血浆TPS、CA125的水平,同时检测20例良性卵巢上皮性肿瘤患者血浆TPS、CA125作为对照.结果 良性卵巢上皮性肿瘤组TPS、CA125平均值在正常范围,卵巢上皮性癌组TPS、CA125平均值远远高于正常值,与对照组比较差异有统计学意义(P<0.05);在介入治疗后患者血浆TPS、CA125水平呈现不同程度的下降,与介入治疗前比较差异有统计学意义(P<0.05).结论 晚期卵巢上皮性癌患者术前动脉介入治疗可以使血浆TPS、CA125水平明显下降,肿瘤体积缩小,提高手术切除率.介入治疗是治疗晚期卵巢癌的一种有效方法.
目的 探討晚期卵巢上皮性癌患者動脈化療灌註及栓塞治療前後血漿組織多肽特異抗原(TPS)、癌抗原125(CA125)的錶達變化,進而評估晚期卵巢上皮性癌患者介入治療的療效及應用價值.方法 對25例晚期卵巢上皮性癌患者術前行髂內動脈、卵巢動脈化療灌註及栓塞,採用ELISA和EIA法檢測患者介入治療前後血漿TPS、CA125的水平,同時檢測20例良性卵巢上皮性腫瘤患者血漿TPS、CA125作為對照.結果 良性卵巢上皮性腫瘤組TPS、CA125平均值在正常範圍,卵巢上皮性癌組TPS、CA125平均值遠遠高于正常值,與對照組比較差異有統計學意義(P<0.05);在介入治療後患者血漿TPS、CA125水平呈現不同程度的下降,與介入治療前比較差異有統計學意義(P<0.05).結論 晚期卵巢上皮性癌患者術前動脈介入治療可以使血漿TPS、CA125水平明顯下降,腫瘤體積縮小,提高手術切除率.介入治療是治療晚期卵巢癌的一種有效方法.
목적 탐토만기란소상피성암환자동맥화료관주급전새치료전후혈장조직다태특이항원(TPS)、암항원125(CA125)적표체변화,진이평고만기란소상피성암환자개입치료적료효급응용개치.방법 대25례만기란소상피성암환자술전행가내동맥、란소동맥화료관주급전새,채용ELISA화EIA법검측환자개입치료전후혈장TPS、CA125적수평,동시검측20례량성란소상피성종류환자혈장TPS、CA125작위대조.결과 량성란소상피성종류조TPS、CA125평균치재정상범위,란소상피성암조TPS、CA125평균치원원고우정상치,여대조조비교차이유통계학의의(P<0.05);재개입치료후환자혈장TPS、CA125수평정현불동정도적하강,여개입치료전비교차이유통계학의의(P<0.05).결론 만기란소상피성암환자술전동맥개입치료가이사혈장TPS、CA125수평명현하강,종류체적축소,제고수술절제솔.개입치료시치료만기란소암적일충유효방법.
Objective To investigate the clinical significance of arteria iliaca interna interventional chemotherapy in patients with advaned stage epithelial ovarian cancer by investigating the different expression of plasma TPS, CA125 before and after interventional chemotherapy. Methods We gave interventional chemotherapy infusion and embolism of arteria iliaca interna and ovarian artery to 25 advanced epithelial ovarian cancer patients. The methods of ELISA and EIA were adopted to detect the level of plasma TPS, CA125 of epithelial ovarian cancer patients before and after interventional treatment. While testing plasma TPS,CA125 of 20 cases of benign epithelial ovarian tumors as control.Results The average level of TPS, CA125 was in the normal range in the group of benign cases. But the level of plasma TPS, CA125 in patients with advanced stage epithelial ovarian cancer was higher than those of benign cases(P＜0.05). After interventional therapy the levels of plasma TPS, CA125 showed different degrees decline. Furthermore there was significant difference between the levels before and after interventional therapy (P<0.05).Conclusions For the patients with advanced stage epithelial ovarian cancer, artery chemotherapy infusion and embolism can make the level of plasma TPS,CA125 decreased, the volume of tumor reduced and the resection rate improved. Interventional therapy is an effective method to treat advanced stage epithelial ovarian cancer.
