CAJ | 학술논문

目的溴隐亭及多巴胺受体D2激动剂会影响除人以外其它灵长类动物的一系列行为,特别是与运动和心理活动相关的行为,比如动物会表现出抑制性行为及幻觉样行为.除药物外,快速眼动睡眠(REM)机制的紊乱也可导致幻觉.打乱清醒、REM及非快速眼动睡眠(NREM)的规律可引起一系列精神病症状.方法当动物处于清醒,NREM和REM及药物导致的类精神病状态时,同时记录五个皮层脑区的听觉诱发电位,从而研究对比不同状态下听觉诱发电位的变化.结果在幻觉状态及REM期,前额叶背外侧皮层记录到的潜伏期为250ms的诱发电位成分出现波峰到基线的相位翻转(PBA250),说明幻觉状态及REM在前额叶背外侧皮层有类似的调节机制.结论在前额叶背外侧皮层记录到的N250可以用来判断幻觉样行为是否出现,这表明前额叶背外侧皮层可能同幻觉样行为最相关.
목적 추은정급다파알수체D2격동제회영향제인이외기타령장류동물적일계렬행위,특별시여운동화심리활동상관적행위,비여동물회표현출억제성행위급환각양행위.제약물외,쾌속안동수면(REM)궤제적문란야가도치환각.타란청성、REM급비쾌속안동수면(NREM)적규률가인기일계렬정신병증상.방법 당동물처우청성,NREM화REM급약물도치적류정신병상태시,동시기록오개피층뇌구적은각유발전위,종이연구대비불동상태하은각유발전위적변화.결과 재환각상태급REM기,전액협배외측피층기록도적잠복기위250ms적유발전위성분출현파봉도기선적상위번전(PBA250),설명환각상태급REM재전액협배외측피층유유사적조절궤제.결론 재전액협배외측피층기록도적N250가이용래판단환각양행위시부출현,저표명전액협배외측피층가능동환각양행위최상관.
Objective Bromocriptine and other dopamine D2 receptor agonists can affect a range of behaviors in nonhuman primates, particularly those behaviors associated with motor and mental function, such as suppressant behaviors and hallucinatory-like behaviors in monkeys. Besides bromocriptine, the dysfunction of the rapid eye movement sleep (REM) mechanism may also contribute to hallucinations. Dissociation of wakefulness, REM, and non-REM (NREM) can cause a series of psychotic symptoms. Methods In present study, we simultaneously recorded auditory evoked potentials (AEP) from five cerebral regions in monkeys during normal and psychotomimetic states to investigate and compare state-dependent changes in AEP. Results Phase reversal of peak-to-baseline amplitude of 250 ms component (PBA250) in dorsolateral prefrontal cortex was common characteristic of hallucinatory-like and REM, and that hallucinatory-like and REM shared the equivalent modulatory orderliness of the PBA250 in dorsolateral prefrontal cortex. This result suggests that hallucinatory-like and REM share an equivalent electrophysiological modulatory in dorsolateral prefrontal cortex. Conclusion Our results reveal that emergence of the N250 in dorsolateral prefrontal cortex is an exclusive marker that may help to discern whether hallucinatory-like behaviors is exhibited, which suggests that dorsolateral prefrontal cortex may be the most pivotal region for exhibition of hallucinatory-like behaviors.