CAJ | 학술논문

糖尿病大血管病变是糖尿病患者致死、致残的首要原因,其主要的病理基础为动脉粥样硬化,但其机制尚未完全阐明.血管旁脂肪组织可分泌众多脂肪细胞因子,研究发现它们不仅参与肥胖、胰岛素抵抗的病理生理过程,还可通过旁分泌和滋养血管分泌“由外至内”作用于血管壁,调节血管张力并参与动脉粥样硬化的发生、发展过程.对血管旁脂肪组织的深入研究将为糖尿病大血管病变的防治提供新靶点.
당뇨병대혈관병변시당뇨병환자치사、치잔적수요원인,기주요적병리기출위동맥죽양경화,단기궤제상미완전천명.혈관방지방조직가분비음다지방세포인자,연구발현타문불부삼여비반、이도소저항적병리생리과정,환가통과방분비화자양혈관분비“유외지내”작용우혈관벽,조절혈관장력병삼여동맥죽양경화적발생、발전과정.대혈관방지방조직적심입연구장위당뇨병대혈관병변적방치제공신파점.
Diabetic macrovascular disease is the leading cause of death and disability of diabetes,its potential pathological basis is atherosclerosis,but the mechanism is not clear.Perivascular adipose tissue (PVAT) can secret numerous adipokines,they not only participate in pathophysiologic process of obesity and insulin resistance,but also play an important role in regulating arterial tone and development of atherosclerosis through the paracrine and vasocrine way from outside to inside.Therefore,to study PVAT thoroughly will provide a new target for prevention and treatment of diabetic macrovascular disease.