CAJ | 학술논문

目的探讨全程三维适形加量放疗治疗食管癌的疗效.方法经病理证实的86例食管癌患者随机分为两组,对照组42例根据钡餐显示的肿瘤侵犯范围在模拟机下透视定位,3个野同中心外照射,总剂量DT 63-70 Gy,7周完成;观察组44例全程运用三维适形计划系统设计个体化治疗方案,使90%的等剂量面包含全部计划靶体积,前程适形照射DT 44～50 Gy,后程缩野总剂量加至DT 66～75 Gy,6周完成.结果观察组和对照组放疗后完全缓解率分别为86.4%、64.3%(x2=4.5420,P＜0.05),两组近期总有效率(CR+PR)分别为93.2%和76.2%(x2=3.6014,P=0.0577),两组毒副反应的差异无显著性意义.结论全程三维适形加量放疗治疗食管癌的近期疗效优于常规方法.
목적 탐토전정삼유괄형가량방료치료식관암적료효.방법 경병리증실적86례식관암환자수궤분위량조,대조조42례근거패찬현시적종류침범범위재모의궤하투시정위,3개야동중심외조사,총제량DT 63-70 Gy,7주완성;관찰조44례전정운용삼유괄형계화계통설계개체화치료방안,사90%적등제량면포함전부계화파체적,전정괄형조사DT 44～50 Gy,후정축야총제량가지DT 66～75 Gy,6주완성.결과 관찰조화대조조방료후완전완해솔분별위86.4%、64.3%(x2=4.5420,P＜0.05),량조근기총유효솔(CR+PR)분별위93.2%화76.2%(x2=3.6014,P=0.0577),량조독부반응적차이무현저성의의.결론 전정삼유괄형가량방료치료식관암적근기료효우우상규방법.
Objective To evaluate the effct of full increase of three-dimensional conformal radiotherapy on esophageal carcinoma.Methods 86 Esophageal cancer patients which has been pathologically confirmed were randomly divided into study group and control group.The control group showed in tumor invasion scope simulator under barium meal positioning,with three fields outside irradiation;Total dose of DT with 63～70 Gy,35 times,seven weeks to complete.Study group showed that full use of additional 3D treatment planning system design individualized treatment programs,90% of the dose contains all planned target volume,future confonnal irradiation DY 44～50 Gy,after the wild-shrinkage increases to a total dose DT66～75 Gy,30 times,completed six weeks.Results The study group and the control group after radiotherapy in a local control rates were 86.4%and 64.3%(x2=4.5420,P＜0.05).Overall response rate(CR+PR)in two group were 93.2%and 76.2%(x2=3.6014,P=0.0577).Two toxicity of the difference was not significant.Conclusion The increase in full three-dimensional conformal radiotherapy of esophageal emleer in the near future is better than conventional methods.