CAJ | 학술논문

局部用抗青光眼药物对眼表的损伤已被大量实验及临床研究证实.眼表损伤不但会给患者带来眼干、眼部充血、眼痒及畏光等不适,还增加了抗青光眼手术失败的风险.抗青光眼药物常用的防腐剂苯扎氯铵在眼表损伤中起重要作用,其毒副作用呈剂量和时间依赖性且在联合用药时增大;其对角膜上皮细胞和角膜内皮细胞均有损伤,对角膜中央厚度也可能有影响.预防眼表损伤是应用抗青光眼药物前必须考虑的问题,目前选择使用复合制剂、不含防腐剂的制剂及含新型防腐剂的制剂可不同程度起到预防抗青光眼药物对眼表损伤的效果.
국부용항청광안약물대안표적손상이피대량실험급림상연구증실.안표손상불단회급환자대래안간、안부충혈、안양급외광등불괄,환증가료항청광안수술실패적풍험.항청광안약물상용적방부제분찰록안재안표손상중기중요작용,기독부작용정제량화시간의뢰성차재연합용약시증대;기대각막상피세포화각막내피세포균유손상,대각막중앙후도야가능유영향.예방안표손상시응용항청광안약물전필수고필적문제,목전선택사용복합제제、불함방부제적제제급함신형방부제적제제가불동정도기도예방항청광안약물대안표손상적효과.
The accumulating evidences from experimental and clinical studies suggested that the ocular surface could be injured by topical anti-glaucoma medications.The ocular surface injury not only caused dry eyes,red eye,eye itching,photophobia and other discomforts,but also increased the risk of failure of glaucoma surgery in patients.The commonly used preservative Benzalkonium Chloride ( BAK )plays an important role in ocular surface damage and its side effects are dose-and time-dependent,particularly,in the combined medications.Topical application of preservative BAK could result in the damage of epithelial cells and endothelial cells,and also affect the central corneal thickness.Prevention of ocular injury should be seriously taken into consideration in the anti-glaucoma medical treatment.Development of complex preparations,preservative-free and/or novel preservative preparations for glaucoma therapy may provide a promising approach in the prevention of ocular surface injury.