CAJ | 학술논문

目的分析45例急性淋巴细胞白血病(acute lymphoblastic leukemia,ALL)成年患者的临床特征与染色体异常之间的相关性,探讨细胞遗传学检查在ALL的诊断及预后中的价值.方法采用荧光原位杂交检测BCR/ABL融合基因和P53基因.采用Log-rank检验比较患者的中位生存期(mediansurvival time,MST).结果白细胞计数(white blood cell count,WBC)≤30×109/L的患者MST高于WBC＞30×109/L者,核型正常者的MST高于核型异常者,无Ph染色体者的MST高于有Ph者,P53无缺失者MST高于P53缺失者,以上差异均有统计学意义(P＜0.05).男女患者的MST差异无统计学意义(P＞0.05).结论 WBC是否＞30×109/L、核型是否异常以及是否伴Ph染色体是成人ALL患者预后的独立因素.
목적 분석45례급성림파세포백혈병(acute lymphoblastic leukemia,ALL)성년환자적림상특정여염색체이상지간적상관성,탐토세포유전학검사재ALL적진단급예후중적개치.방법 채용형광원위잡교검측BCR/ABL융합기인화P53기인.채용Log-rank검험비교환자적중위생존기(mediansurvival time,MST).결과 백세포계수(white blood cell count,WBC)≤30×109/L적환자MST고우WBC＞30×109/L자,핵형정상자적MST고우핵형이상자,무Ph염색체자적MST고우유Ph자,P53무결실자MST고우P53결실자,이상차이균유통계학의의(P＜0.05).남녀환자적MST차이무통계학의의(P＞0.05).결론 WBC시부＞30×109/L、핵형시부이상이급시부반Ph염색체시성인ALL환자예후적독립인소.
[Objective]To analyze the correlation between clinical features and cytogenetic finding of 45 adult patients with acute lymphoblastie leukemia (ALL),and to assess the value of chromosomal examination for the diagnosis and prognosis.[Methods] Fluorescence in situ hybridization (FISH) was utilized for detecting the BCR/ABL fusion gene and P53 gene.Median survival time (MST) of patients was compared using Log-rank test.[Results] Respectively,the MST of patients with white blood cell count (WBC)≤30×109/L,normal karyotype,or without a Philadelphia chromosome were significantly greater than those with WBC＞30×109/L,abnormal karyotype or Philadelphia chromosome (P＞0.05).[Conclusion] WBC,karyotype abnormalities and presence of Philadelphia chromosome are independent factors for the prognosis of ALL in adult patients.