CAJ | 학술논문

目的研究光动力学疗法治疗上消化道癌的近期疗效及毒副反应.方法临床各期上消化道癌患者56例,男性37例,女性19例,平均年龄65.6岁.应用630-PDT半导体激光器作为治疗光源,激光波长630nm,功率密度200～400mW/cm,能量密度100～300J/cm.光敏剂为PHOTOFRIN,按2mg/kg于照光前12～24h静脉滴注.结果完成治疗的56例患者中,完全效应6例(占10.7%),明显效应33例(占58.9%),稍有效应12例(占21.4%),无效5例(占8.9%).总有效率(CR+PR)为69.6%.所有病例均未出现严重毒副反应.结论光动力学疗法治疗临床各期上消化道癌疗效肯定,毒副反应轻,耐受性好,是一种较好的姑息治疗手段.
목적연구광동역학요법치료상소화도암적근기료효급독부반응.방법림상각기상소화도암환자56례,남성37례,녀성19례,평균년령65.6세.응용630-PDT반도체격광기작위치료광원,격광파장630nm,공솔밀도200～400mW/cm,능량밀도100～300J/cm.광민제위PHOTOFRIN,안2mg/kg우조광전12～24h정맥적주.결과완성치료적56례환자중,완전효응6례(점10.7%),명현효응33례(점58.9%),초유효응12례(점21.4%),무효5례(점8.9%).총유효솔(CR+PR)위69.6%.소유병례균미출현엄중독부반응.결론광동역학요법치료림상각기상소화도암료효긍정,독부반응경,내수성호,시일충교호적고식치료수단.
Objective: To evaluate the clinical effectiveness and adverse effects of photodynamic therapy (PDT) for the upper gastrointestinal tract cancers. Methods: 56 patients with upper gastrointestinal cancers in different clinical stages were treated with PDT. Diode laser (630 nm) was used as the light source and the parameters were as follows: power density 200 to 400 mW/cm, energy density 100 to 300 J/cm. PHOTOFRIN was used as photosensitizer, which was given in a dose of 2 mg/kg intravenously 12-24 h before irradiation. Results: Evaluation of the 56 patients' therapeutic effectiveness showed that 6 patients (10.7%) had a complete response (CR), 33 patients (58.9%) partial response (PR), 12 patients (21.4%) mild response (MR), and 5 patients (8.9%) no response (NR). The total response rate (CR+PR) was 69.6%. No patients had severe adverse effects in this group. Conclusion: PDT is an effective and safe palliative modality for upper gastrointestinal tract cancers.