CAJ | 학술논문

目的探讨血清基质金属蛋白酶2(MMP-2)、基质金属蛋白酶9(MMP-9)及其组织抑制物1(TIMP-1)与糖尿病足(DF)之间的关联.方法采用酶联免疫吸附法对22例糖尿病足患者(DF组)、23例单纯2型糖尿病患者(T2DM组)及25名健康对照者(NC组)进行MMP-2、MMP-9及TIMP-1水平检测,并分析其关联.结果 DF组MMP-2、MMP-9水平明显高于NC组及T2DM组(P＜0.01或P＜0.05);DF组及T2DM组TIMP-1水平明显低于NC组(P＜0.01或P＜0.05),而DF组和T2DM组间无统计学差异(P＞0.05);未发现与MMP-2、MMP-9及TIMP-1水平显著相关的临床生化指标.结论 DF患者的MMP-2、MMP-9水平高于单纯T2DM患者,而TIMP-1水平未出现改变.
목적 탐토혈청기질금속단백매2(MMP-2)、기질금속단백매9(MMP-9)급기조직억제물1(TIMP-1)여당뇨병족(DF)지간적관련.방법 채용매련면역흡부법대22례당뇨병족환자(DF조)、23례단순2형당뇨병환자(T2DM조)급25명건강대조자(NC조)진행MMP-2、MMP-9급TIMP-1수평검측,병분석기관련.결과 DF조MMP-2、MMP-9수평명현고우NC조급T2DM조(P＜0.01혹P＜0.05);DF조급T2DM조TIMP-1수평명현저우NC조(P＜0.01혹P＜0.05),이DF조화T2DM조간무통계학차이(P＞0.05);미발현여MMP-2、MMP-9급TIMP-1수평현저상관적림상생화지표.결론 DF환자적MMP-2、MMP-9수평고우단순T2DM환자,이TIMP-1수평미출현개변.
Objective To explore the association of levels of serum matrix matalloproteinase (MMP-2) and (MMP-9) and its tissue inhibitor-1 of matrix metalloproteinase-1 (TIMP-1) with the pathogenesis of diabetic foot. Methods The levels of serum MMP-2, MMP-9 and TIMP-1 were measured by ELISA in 22 patients with diabetic foot, 23 type 2 diabetic patients without any complications and 25 normal controls. Results The levels of MMP-2 and MMP-9 in diabetic foot patients were extremely higher than in type 2 diabetic patients and controls. The levels of TIMP-1 in patients with diabetic foot and type 2 diabetes mellitus were lower than in controls, while there was no significant difference between diabetic foot patients and type 2 diabetic patients. There was no correlation of MMP-2, MMP-9 and TIMP-1 with indexes of age, BP, lipids, HbA1c, UA and serum creatinine. Conclusion Patients with diabetic foot have higher levels of MMP2 and MMP-9 than patients with pure diabetes, and have the same level of TIMP-1.