CAJ | 학술논문

目的:探讨急性脑梗死(acute cerebral infarction,ACI)合并阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syndrome,OSAHS)患者血清肿瘤坏死因子(tumor necrosis factor alpha,TNF-α)和超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)水平变化及临床意义.方法:分别采用双抗体夹心ELISA和乳胶增强免疫比浊法测定32例健康体检者、36例ACI、28例OSAHS以及30例ACI合并OSAHS患者血清TNF-α和hs-CRP水平,同时记录各组睡眠呼吸暂停低通气指数(apnea-hypopnea index,AHI).结果:ACI组、OSAHS组、ACI合并OSAHS组血清TNF-α、hs-CRP水平明显高于正常对照组(P<0.01);ACI合并OSAHS组血清TNF-α、hs-CRP水平明显高于ACI组(P<0.01),也明显高于OSAHS组(P<0.01).OSAHS组、ACI合并OSAHS组AHI明显高于ACI组和正常对照组(P<0.01);ACI合并OSAHS组AHI明显高于OSAHS组(P<0.01).结论:ACI及OSAHS患者均存在炎症反应,ACI合并OSAHS患者炎症反应的水平更高,OSAHS可能通过增强炎症级联反应的途径促进ACI的发生发展,通过抗炎治疗可能对ACI合并OSAHS患者预后有一定改善.
목적:탐토급성뇌경사(acute cerebral infarction,ACI)합병조새성수면호흡잠정저통기종합정(obstructive sleep apnea-hypopnea syndrome,OSAHS)환자혈청종류배사인자(tumor necrosis factor alpha,TNF-α)화초민C반응단백(high-sensitivity C-reactive protein,hs-CRP)수평변화급림상의의.방법:분별채용쌍항체협심ELISA화유효증강면역비탁법측정32례건강체검자、36례ACI、28례OSAHS이급30례ACI합병OSAHS환자혈청TNF-α화hs-CRP수평,동시기록각조수면호흡잠정저통기지수(apnea-hypopnea index,AHI).결과:ACI조、OSAHS조、ACI합병OSAHS조혈청TNF-α、hs-CRP수평명현고우정상대조조(P<0.01);ACI합병OSAHS조혈청TNF-α、hs-CRP수평명현고우ACI조(P<0.01),야명현고우OSAHS조(P<0.01).OSAHS조、ACI합병OSAHS조AHI명현고우ACI조화정상대조조(P<0.01);ACI합병OSAHS조AHI명현고우OSAHS조(P<0.01).결론:ACI급OSAHS환자균존재염증반응,ACI합병OSAHS환자염증반응적수평경고,OSAHS가능통과증강염증급련반응적도경촉진ACI적발생발전,통과항염치료가능대ACI합병OSAHS환자예후유일정개선.