国际生物医学工程杂志
國際生物醫學工程雜誌
국제생물의학공정잡지
INTERNATIONAL JOURNAL OF BIOMEDICAL ENGINEERING
2009年
2期
73-77
,共5页
王为超%谢慧%薛骏%周庆文%孔德领%俞耀庭
王為超%謝慧%薛駿%週慶文%孔德領%俞耀庭
왕위초%사혜%설준%주경문%공덕령%유요정
血脂%过滤%吸附%脑卒中%体外评价
血脂%過濾%吸附%腦卒中%體外評價
혈지%과려%흡부%뇌졸중%체외평개
Lipoprotein%Filtration%Adsorption%Stroke%In vitro evaluation
目的 对一种新型体外血浆脂类吸附过滤器JX-DELP进行性能评价.方法 ①通过体外静态吸附实验检验过滤器滤膜对血脂的吸附效果.②模拟过滤器产品结构组成,设计并加工了小型血浆过滤装置.使用该装置模拟临床应用条件,考察了血浆用量、过滤速度和时间对过滤吸附效果的影响;考察了循环过滤方式对高脂血症患者血浆的综合过滤吸附效果.③考察滤膜与全血直接接触条件下材料的血液相容性.结果 过滤器的滤膜在体外对血脂的清除率分别为:总胆固醇(TO)16.7%,甘油三酯(TG)9.7%,低密度脂蛋白(LDL)13.5%.在体外循环实验中,在一定的血浆处理体积、过滤速度和时间内,对TC、TG和LDL的清除率分别为52.0%、50.1%和38.4%.血浆其他组分的浓度变化不显著.过滤器滤膜对全血各组分无显著破坏作用,溶血率仅为0.19%.具有良好的血液相容性.结论 体外血浆脂类吸附过滤装置,JX-DELP,能快速有效地去除高脂血症患者血浆中含量过高的血脂,而不会对血液其他组分产生破坏作用,同时滤膜本身有很好的血液相容性.该装置可用于降低血脂和血黏度,临床治疗某些高血脂相关疾病.
目的 對一種新型體外血漿脂類吸附過濾器JX-DELP進行性能評價.方法 ①通過體外靜態吸附實驗檢驗過濾器濾膜對血脂的吸附效果.②模擬過濾器產品結構組成,設計併加工瞭小型血漿過濾裝置.使用該裝置模擬臨床應用條件,攷察瞭血漿用量、過濾速度和時間對過濾吸附效果的影響;攷察瞭循環過濾方式對高脂血癥患者血漿的綜閤過濾吸附效果.③攷察濾膜與全血直接接觸條件下材料的血液相容性.結果 過濾器的濾膜在體外對血脂的清除率分彆為:總膽固醇(TO)16.7%,甘油三酯(TG)9.7%,低密度脂蛋白(LDL)13.5%.在體外循環實驗中,在一定的血漿處理體積、過濾速度和時間內,對TC、TG和LDL的清除率分彆為52.0%、50.1%和38.4%.血漿其他組分的濃度變化不顯著.過濾器濾膜對全血各組分無顯著破壞作用,溶血率僅為0.19%.具有良好的血液相容性.結論 體外血漿脂類吸附過濾裝置,JX-DELP,能快速有效地去除高脂血癥患者血漿中含量過高的血脂,而不會對血液其他組分產生破壞作用,同時濾膜本身有很好的血液相容性.該裝置可用于降低血脂和血黏度,臨床治療某些高血脂相關疾病.
목적 대일충신형체외혈장지류흡부과려기JX-DELP진행성능평개.방법 ①통과체외정태흡부실험검험과려기려막대혈지적흡부효과.②모의과려기산품결구조성,설계병가공료소형혈장과려장치.사용해장치모의림상응용조건,고찰료혈장용량、과려속도화시간대과려흡부효과적영향;고찰료순배과려방식대고지혈증환자혈장적종합과려흡부효과.③고찰려막여전혈직접접촉조건하재료적혈액상용성.결과 과려기적려막재체외대혈지적청제솔분별위:총담고순(TO)16.7%,감유삼지(TG)9.7%,저밀도지단백(LDL)13.5%.재체외순배실험중,재일정적혈장처리체적、과려속도화시간내,대TC、TG화LDL적청제솔분별위52.0%、50.1%화38.4%.혈장기타조분적농도변화불현저.과려기려막대전혈각조분무현저파배작용,용혈솔부위0.19%.구유량호적혈액상용성.결론 체외혈장지류흡부과려장치,JX-DELP,능쾌속유효지거제고지혈증환자혈장중함량과고적혈지,이불회대혈액기타조분산생파배작용,동시려막본신유흔호적혈액상용성.해장치가용우강저혈지화혈점도,림상치료모사고혈지상관질병.
Objective To evaluate the performance of a novel extracorporeal hpoprotein filter,JX-DELP.Methods The adsorptionof the filter membrane to lipoproteins was examined by in-vitro static adaorption method.A pocket filter which simulates the product,JX-DELP,W88 designed and made.An extracorporeal circulation system was established using the pocket filter and clinical application was imitated.The influences of plasma volume,flow rate and filtering time on the removal of lipopmteins were tested in a flow condition.The biocompatibility of the falter Was evaluated by incubating the membrane with whole blood.Results The in vitro removal rates of the filter membrane to lipeproteim are:TC 16.7%,TG 9.7%,and LDL 13.5%,respeetaively.In the extracorporeal circulation systemthe removals of TC,TG,and LDL were 52.0%,50.1%,and 38.4%,respectively.However,the reductions of other components in plasma were negligible.The filter membroJle did not change the normal components in the whole blood,and the hemolysis rate was low as 0.19%.It suggests that the filter has good blood compatibility.Conclusion The llish level of lipoproteins in hyperlipeidemia patients could be efficiently removed by the novel extracorpereal hpoprotein filter,JX-DELP.It may be effective in treatment of hyperlipoidemia related diseases.