CAJ | 학술논문

目的研究血清降钙素原(PCT)检测在支气管哮喘急性加重患者治疗时抗生素使用中的指导作用.方法选取2007年2月至2009年7月间复旦大学附属上海市第五人民医院的哮喘急性加重患者158例,随机(随机数字法)分配到两组:PCT指导治疗组77例(PCT组)和常规治疗组81例(对照组),检测血清PCT水平.在相同常规治疗基础上,对照组由经治医师按照抗生素使用指南决定是否使用抗生素,PCT组按照血清PCT水平决定是否使用抗生素,在血清PCT≥0.25 ng/mL时,进行抗生素治疗,PCT＜0.25ng/mL时,不予抗生素治疗.观察两组患者的抗生素使用率.采用t检验、x2检验及Mann-Whitney U检验进行统计学分析.结果 PCT组的抗生素使用率(45.4%)低于对照组(77.8%)(x2=17.51,P=0.000),两者预后没有明显差异.结论支气管哮喘急性加重患者可在PCY指导下安全使用抗生素,能够降低抗生素使用率.
목적 연구혈청강개소원(PCT)검측재지기관효천급성가중환자치료시항생소사용중적지도작용.방법 선취2007년2월지2009년7월간복단대학부속상해시제오인민의원적효천급성가중환자158례,수궤(수궤수자법)분배도량조:PCT지도치료조77례(PCT조)화상규치료조81례(대조조),검측혈청PCT수평.재상동상규치료기출상,대조조유경치의사안조항생소사용지남결정시부사용항생소,PCT조안조혈청PCT수평결정시부사용항생소,재혈청PCT≥0.25 ng/mL시,진행항생소치료,PCT＜0.25ng/mL시,불여항생소치료.관찰량조환자적항생소사용솔.채용t검험、x2검험급Mann-Whitney U검험진행통계학분석.결과 PCT조적항생소사용솔(45.4%)저우대조조(77.8%)(x2=17.51,P=0.000),량자예후몰유명현차이.결론 지기관효천급성가중환자가재PCY지도하안전사용항생소,능구강저항생소사용솔.
Objective To evaluate the value of serum procalcitonin (PCT) in antibiotics used for the treatment of acute exacerbation of asthma. Method From February 2007 to July 2009, a total of 158 patients with asthma were randomly (random number) assigned to PCT group ( n = 77) or to control group ( n = 81 ). The PCT levels of all patients were measured. On the bases of routine treatment, the employment of antibiotics in control group was determined by the guidebook, and patients in the PCT group were treated with antibiotics guided by the levels of serum PCT. The antibiotics treatment was employed as PCT level ＞0.25 ng/mL, and was not employed as PCT level ＜ 0.25 ng/mL. The rates of antibioties employment were observed. Results The rate of antibiotics employment in PCT group (45.4%) was lower than that of the control group (77.8%) (x2 = 17.15,P =0.000). Conclusions PCT could be used safely as guidance of antibiotics employment for the treatment of patients with acute exacerbation of asthma, leading to appropriate use of antibiotcs.