CAJ | 학술논문

目的探讨己酮可可碱联合机械通气治疗急性呼吸窘迫综合征(ARDS)的临床疗效.方法将64例ARDS患者随机分为对照组和己酮可可碱组(PTX组)各32例.对照组采用常规治疗,PTX组患者在此基础上加用己酮可可碱注射液200 mg,每日2次.观察两组患者治疗效果、血气分析指标及血清中肿瘤坏死因子α(TNF-α)、白细胞介素8(IL-8)含量变化.结果治疗后3、7 d两组患者动脉血氧分压(PaO_2)、氧合指数(PaO_2/FiO_2)差异有统计学意义(P＜0.05),PTX组血清TNF-α、IL-8及病死率均低于对照组(P＜0.05).结论 PTX联合机械通气治疗能够有效阻抑ARDS患者的炎性反应,改善患者氧合情况和预后.
목적 탐토기동가가감연합궤계통기치료급성호흡군박종합정(ARDS)적림상료효.방법 장64례ARDS환자수궤분위대조조화기동가가감조(PTX조)각32례.대조조채용상규치료,PTX조환자재차기출상가용기동가가감주사액200 mg,매일2차.관찰량조환자치료효과、혈기분석지표급혈청중종류배사인자α(TNF-α)、백세포개소8(IL-8)함량변화.결과 치료후3、7 d량조환자동맥혈양분압(PaO_2)、양합지수(PaO_2/FiO_2)차이유통계학의의(P＜0.05),PTX조혈청TNF-α、IL-8급병사솔균저우대조조(P＜0.05).결론 PTX연합궤계통기치료능구유효조억ARDS환자적염성반응,개선환자양합정황화예후.
Objective To explorer the clinical effects of Pentoxifylline(PTX group) with mechanical ventilation in patients with acute respiratory distress syndrome(ARDS). Methods 64 patients with ARDS were randomized into a control group(n = 32 ,ARDS conventional treatment) and a PTX group(n = 32 ,PTX 50ml iv bid in addition to the conventional treatment). The patients were closely monitored with their curative effect, blood gas indexes and serum levels of TNF-α and IL-8 after the treatment. Results The PaO_2 and PaO_2/FiO_2 got significantly higher in the PTX group than in the control group on 3d and 7d (P ＜ 0.05). The serum levels of TNF-α and IL-8 and the mortality of ARDS were significantly decreased in the PTX group after the combined with Pentoxifylline (P ＜ 0.05 or P ＜0.01). Conclusion The treatment combined with the Pentoxifylline can effectively improve the Oxygenation and prognosis of ARDS patients by inhibiting the inflammatory responses.