CAJ | 학술논문

目的研究糖皮质激素单药及联合环磷酰胺治疗甲状腺相关眼病的疗效.方法回顾性分析应用单纯糖皮质激素(单药组,甲泼尼龙)的35例患者和糖皮质激素联合环磷酰胺(联合组,泼尼松+环磷酰胺)治疗的16例患者的临床资料.结果联合组总有效率(93.8％)显著高于单药组(68.6％)(x2=3.87,P＜0.05).单纯应用糖皮质激素对CAS评分、突眼度、软组织炎症评分均有显著治疗效果,但疗效显著低于联合组(P＜0.05).两组不良反应发生率差异无统计学意义.结论联合糖皮质激素和环磷酰胺较单纯应用糖皮质激素,对甲状腺相关眼病的疗效更好,不良反应更低,尤其适合对激素治疗无效或效果不佳的患者.
목적 연구당피질격소단약급연합배린선알치료갑상선상관안병적료효.방법 회고성분석응용단순당피질격소(단약조,갑발니룡)적35례환자화당피질격소연합배린선알(연합조,발니송+배린선알)치료적16례환자적림상자료.결과 연합조총유효솔(93.8％)현저고우단약조(68.6％)(x2=3.87,P＜0.05).단순응용당피질격소대CAS평분、돌안도、연조직염증평분균유현저치료효과,단료효현저저우연합조(P＜0.05).량조불량반응발생솔차이무통계학의의.결론 연합당피질격소화배린선알교단순응용당피질격소,대갑상선상관안병적료효경호,불량반응경저,우기괄합대격소치료무효혹효과불가적환자.
Objective To explore the effect of single glucocorticoid treatment and glucocorticoid joint cyclophosphamide treatment on thyroid-associated ophthalmopathy.Methods Retrospective analysis of clinical data of 35patients used single glucocorticoid( single medicine group) and 16 patients used glucocorticoids joint cyclophosphamide(joint group) was carried out.Results The effective rate of joint group(93.8％ ) was significantly higher than single drug group (68.6％) ( x2 =3.87,P ＜ 0.05).Simple using glucocorticoid had significant treatment effect at CAS score,prominent eyes degrees,soft tissue inflammation score,but the curative effect was significantly lower than the joint group ( P ＜ 0.05 ).The adverse reaction rate had no significant difference between two groups.Conclusion Compared to single glucocorticoid treatment,the glucocorticoid joint cyclophosphamide treatment had better effect and lower adverse reaction rate,especially suitable for patients who had no effect or low effect on hormone therapy.