中华临床感染病杂志
中華臨床感染病雜誌
중화림상감염병잡지
CHINESE JOURNAL OF CLINICAL INFECTIOUS DISEASES
2008年
3期
153-155
,共3页
潘越峻%应若素%范慧敏%张春兰%唐小平
潘越峻%應若素%範慧敏%張春蘭%唐小平
반월준%응약소%범혜민%장춘란%당소평
肝炎,慢性%干扰素%甲状腺功能异常
肝炎,慢性%榦擾素%甲狀腺功能異常
간염,만성%간우소%갑상선공능이상
Chronic hepatitis%Interferon%Thyroid dysfunction
目的 探讨IFNα治疗慢性肝炎期间甲状腺功能异常情况及其临床特点.方法 对310例应用IFNα治疗的慢性肝炎患者的甲状腺功能进行评估.结果 治疗前,所有患者的血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、敏感促甲状腺素(sTSH)均正常,甲状腺球蛋白抗体(TGAb)阴性;应用IFNα治疗后,10例(10/310,3.22%)患者出现甲状腺功能异常,其中7例患者血清生化学改变符合甲状腺功能减退症,3例患者符合甲状腺功能亢进症.随访1年后,所有患者的甲状腺功能恢复正常.结论 IFNα治疗慢性肝炎过程中可诱发甲状腺功能异常,采取相应治疗措施后预后良好.
目的 探討IFNα治療慢性肝炎期間甲狀腺功能異常情況及其臨床特點.方法 對310例應用IFNα治療的慢性肝炎患者的甲狀腺功能進行評估.結果 治療前,所有患者的血清遊離三碘甲狀腺原氨痠(FT3)、遊離甲狀腺素(FT4)、敏感促甲狀腺素(sTSH)均正常,甲狀腺毬蛋白抗體(TGAb)陰性;應用IFNα治療後,10例(10/310,3.22%)患者齣現甲狀腺功能異常,其中7例患者血清生化學改變符閤甲狀腺功能減退癥,3例患者符閤甲狀腺功能亢進癥.隨訪1年後,所有患者的甲狀腺功能恢複正常.結論 IFNα治療慢性肝炎過程中可誘髮甲狀腺功能異常,採取相應治療措施後預後良好.
목적 탐토IFNα치료만성간염기간갑상선공능이상정황급기림상특점.방법 대310례응용IFNα치료적만성간염환자적갑상선공능진행평고.결과 치료전,소유환자적혈청유리삼전갑상선원안산(FT3)、유리갑상선소(FT4)、민감촉갑상선소(sTSH)균정상,갑상선구단백항체(TGAb)음성;응용IFNα치료후,10례(10/310,3.22%)환자출현갑상선공능이상,기중7례환자혈청생화학개변부합갑상선공능감퇴증,3례환자부합갑상선공능항진증.수방1년후,소유환자적갑상선공능회복정상.결론 IFNα치료만성간염과정중가유발갑상선공능이상,채취상응치료조시후예후량호.
Objective To investigate the prevalence and clinical characteristics of thyroid dysfunction induced by IFNα therapy in patients with chronic hepatitis.Methods Thyroid function of 310 patients with chronic hepatitis receiving IFNα therapy were evaluated.Results Serum free tri-iodothymnine (F13),free thyroxine(FT4)and sensitive thyroid-stimulating hormone(sTSH)of all patients were normal and TGAb was negative before IFNα therapy.After the treatment,10 patients(10/3 10,3.22%)had thyroid dysfunction,in which 7 were of hypothyroidism and 3 were of hyperthyroidism.The thyroid function of all patients recovered within 1-year follow-up.Conclusions IFNα therapy may induce thyroid dysfunction in patients with chronic hepatitis,in which prognosis can be good when appropriate treatment is given.
