CAJ | 학술논문

目的检测类风湿关节炎(RA)患者血清中肿瘤坏死因子样凋亡微弱诱导剂(TWEAK)和凋亡调节蛋白生存素(survivin)的水平,以探讨其在RA中的意义.方法采用酶联免疫吸附试验(ELISA)方法测定61例RA患者和35名健康对照组血清中TWEAK和survivin水平,同时测定RA患者关节功能、X线分期、关节压痛数和肿胀数、红细胞沉降率、类风湿因子、C反应蛋白等各项临床指标,进行相关性分析.结果 RA患者血清中TWEAK水平[(479±381)pg/ml]与健康对照组TWEAK水平[(421±87)pg/ml]差异无统计学意义.RA患者血清中survivin水平[(159±82)pg/ml]比对照组[(119±24)pg/ml]增高(P＜0.05),且血清gurvivin水平与RA患者关节X线分期呈正相关(r=0.29,P＜0.05).结论血清TWEAK水平与RA的关系还需要更深入的研究.Survivin与关节侵蚀性相关,可能成为新的判断病情及治疗的新指标.
목적 검측류풍습관절염(RA)환자혈청중종류배사인자양조망미약유도제(TWEAK)화조망조절단백생존소(survivin)적수평,이탐토기재RA중적의의.방법 채용매련면역흡부시험(ELISA)방법측정61례RA환자화35명건강대조조혈청중TWEAK화survivin수평,동시측정RA환자관절공능、X선분기、관절압통수화종창수、홍세포침강솔、류풍습인자、C반응단백등각항림상지표,진행상관성분석.결과 RA환자혈청중TWEAK수평[(479±381)pg/ml]여건강대조조TWEAK수평[(421±87)pg/ml]차이무통계학의의.RA환자혈청중survivin수평[(159±82)pg/ml]비대조조[(119±24)pg/ml]증고(P＜0.05),차혈청gurvivin수평여RA환자관절X선분기정정상관(r=0.29,P＜0.05).결론 혈청TWEAK수평여RA적관계환수요경심입적연구.Survivin여관절침식성상관,가능성위신적판단병정급치료적신지표.
Objective To measure the serum levels of TWEAK and survivin in rheumatoid arthritis (RA)patients and explore their clinical value. Methods The serum levels of TWEAK and survivin were measured by ELISA methods in 61 patients with RA and 35 healthy controls. The function stage, X-ray stage,and serum levels of ESR, RF and CRP were measured at the same time. Results There was no significant difference between the serum levels of TWEAK in patients with RA[(479±381)pg/ml]and control[(421±87 pg/ml]. The serum level of survivn in patients with RA[(159±82)pg/ml]was increased significantly than that of the controls[(119±24)pg/ml]and were associated with X-ray stage. Conclusion We need further research to explore the relationship between TWEAK and RA. The serum level of survivin is associated with chronic erosive RA and maybe a target for new therapeutic approach of RA.