CAJ | 학술논문

临床及基础研究已经发现,巨噬细胞能够诱发肿瘤并促进其恶化进程.巨噬细胞的聚集提示肿瘤预后不佳;在肿瘤起始阶段,巨噬细胞创造炎症环境,致细胞突变并促进其生长.随着肿瘤的发展,巨噬细胞在肿瘤即将转移至的部位,为肿瘤细胞的到来提前制造转移前生态位;继而,巨噬细胞又在肿瘤转移后的初始增殖中发挥重要的营养作用.目前,随着对巨噬细胞相关研究的不断进展,相信必然能为肿瘤治疗开辟新的方向.
림상급기출연구이경발현,거서세포능구유발종류병촉진기악화진정.거서세포적취집제시종류예후불가;재종류기시계단,거서세포창조염증배경,치세포돌변병촉진기생장.수착종류적발전,거서세포재종류즉장전이지적부위,위종류세포적도래제전제조전이전생태위;계이,거서세포우재종류전이후적초시증식중발휘중요적영양작용.목전,수착대거서세포상관연구적불단진전,상신필연능위종류치료개벽신적방향.
There is persuasive clinical and experimental evidence that macrophages promote cancer initiation and malignant progression. The aggregation of macrophages indicates poor prognosis of tumor associated diseases. During tumor initiation, macrophages create an inflammatory environment that is mutagenic to cells and promotes cell growth; as tumors progressing, macrophages create premetastatic niche for the arriving tumor cells at premetastatic sites ; then macrophages provide critical nutrients for these initial metastatic tumor cells.Along with these great achievements in research of macrophage, it is believed that several novel directions of tumor therapy surely occur in the future.