CAJ | 학술논문

目的探讨8-异构前列腺素F2α(8-iso-PGF2α)和超敏C-反应蛋白(hs-CRP)的血清水平在监测冠心病病情方面的作用及与冠状动脉病变程度的关系.方法冠心病患者153例,按临床诊断分为急性心肌梗死(AMI)组52例、不稳定型心绞痛(UAP)组50例、稳定型心绞痛(SAP)组51例;对照组50例.测定各组hs-CRP、8-iso-PGF2α的水平.结果 AMI组、UAP组及SAP组的8-iso-PGF2α(mg/L)分别为(524.12±0.67)、(327.24±0.78)、(127.38±1.29);hs-CRP(mg/L)分别为(18.16±0.77)、(13.76±1.13)、(7.64±0.98);均比对照组高(均P＜0.05);AMI组、UAP组和SAP组8-iso-PGF2α和hs-CRp水平相比,差异均有统计学意义(均P＜0.05);8-iso-PGF2α和hs-CRp水平变化呈正相关.结论血清8-iso-PGF2α和hs-CRP可能是冠状动脉粥样硬化的标志,参与了冠心病的发病过程,其水平与冠状动脉病变程度密切相关.
목적 탐토8-이구전렬선소F2α(8-iso-PGF2α)화초민C-반응단백(hs-CRP)적혈청수평재감측관심병병정방면적작용급여관상동맥병변정도적관계.방법 관심병환자153례,안림상진단분위급성심기경사(AMI)조52례、불은정형심교통(UAP)조50례、은정형심교통(SAP)조51례;대조조50례.측정각조hs-CRP、8-iso-PGF2α적수평.결과 AMI조、UAP조급SAP조적8-iso-PGF2α(mg/L)분별위(524.12±0.67)、(327.24±0.78)、(127.38±1.29);hs-CRP(mg/L)분별위(18.16±0.77)、(13.76±1.13)、(7.64±0.98);균비대조조고(균P＜0.05);AMI조、UAP조화SAP조8-iso-PGF2α화hs-CRp수평상비,차이균유통계학의의(균P＜0.05);8-iso-PGF2α화hs-CRp수평변화정정상관.결론 혈청8-iso-PGF2α화hs-CRP가능시관상동맥죽양경화적표지,삼여료관심병적발병과정,기수평여관상동맥병변정도밀절상관.
Objective To study the correlation between 8-Iosmerie Porastglnadin-2a(8-iso-PGF2α) 、hypersensitive C-reactive protein(hs-CRP) and coronary heart disease(CHD). Methods 153 CHD patients were divided into 3 groups,including 52 cases of acute myocardial infarction(AMI) ,50 cases of unstable angina(UAP) ,51 cases of stable angina(SAP) and control group consisted of 50 healthy people. The levels of hs-CRP and 8-iso-PGF2α were measured. Person correlation analysis was used to analyze the relationship between the level of hs-CRP and 8-isoPGF2α. Results The levels of hs-CRP and 8-iso-PGF2α were significantly higher in AMI, UAP and SAP group than those in control group(all P ＜0.05). Compared with SAP group,the levels of hs-CRP and 8-iso-PGF2α were increased in AMI and UAP groups (all P ＜ 0. 05) . The level of hs-CRP was positively associated with the level of 8-iso-PGF2α. Conclusion hs-CRP and 8-iso-PGF2α should be the markers of coronary atherosclerosis and involved in the process of CHD. The levels of serum hs-CRP and 8-iso-PGF2α were correlated with the severity of CHD.