CAJ | 학술논문

目的研究造血干细胞移植患者出血并发症的防治措施.方法对32例行造血干细胞移植的血液病患者进行回顾性分析,观察其在移植后骨髓空虚期采用的防治出血措施的疗效.结果除1例伴有脾脏肿大的重型β地中海盆血患儿(行无关供者脐血移植)出血症状无好转,血小板数量无明显提高,最终死于颅内出血外,其余31例患者的出血症状均很快得以控制,血小板数量上升,安全度过无髓期.结论在造血干细胞移植后骨髓空虚期,及时采用输注新鲜单采血小板、应用止血药物及糖皮质激素等措施,能够有效控制患者出血并发症的发生.
목적연구조혈간세포이식환자출혈병발증적방치조시.방법대32례행조혈간세포이식적혈액병환자진행회고성분석,관찰기재이식후골수공허기채용적방치출혈조시적료효.결과제1례반유비장종대적중형β지중해분혈환인(행무관공자제혈이식)출혈증상무호전,혈소판수량무명현제고,최종사우로내출혈외,기여31례환자적출혈증상균흔쾌득이공제,혈소판수량상승,안전도과무수기.결론재조혈간세포이식후골수공허기,급시채용수주신선단채혈소판、응용지혈약물급당피질격소등조시,능구유효공제환자출혈병발증적발생.
Objective: To study the measures of prevention and treatment for hemorrhagic complications in recipients of hematopoietic stem cell transplantation. Methods: 32 patients with hematological disorders undergoing hematopoietic stem cell transplantation were retrospectively analyzed to observe the effect of methods adopted to prevent and treat hemorrhage during aplastic stage after transplantation. Results: In only one child of β-thalassemia major with splenomegaly undergoing cord blood transplantation from an unrelated donor, that hemorrhagic symptoms were not controlled, platelet counts did not increase significantly and then he died of cerebral hemorrhage. In the other 31 patients, the hemorrhagic symptoms were controlled, platelet counts increased and they totally recovered. Conclusions: During the aplastic stage after hematopoietic stem cell transplantation, transfusion of platelet, anti-hemorrhage drugs and glucocorticoid were proved to be effectual methods to control the hemorrhagic complications of patients.