CAJ | 학술논문

目的分析乙肝病毒B基因型和C基因型B细胞表位的差异及意义.方法通过互联网从GenBank搜索乙HF病毒B基因型和C基因型的S蛋白氨基酸序列,使用DANStar生物学软件多个参数预测B细胞抗原表位,并在互联网服务器上用Kolaskear-tongaonakar法预测乙肝病毒B基因型和C基因型的S蛋向的B细胞抗原位点.结果综合预测乙肝病毒B基因型和C基因型S蛋白的B细胞抗原位点,B基因型的S蛋白有5个B细胞抗原位点,C基闪型的S蛋白有3个B细胞抗原位点,并且B基因型的B细胞抗原位点的综合抗原指数(1.0798)高于C基因型的B细胞抗原位点的综合抗原指数(1.0729).结论肝炎病毒C基因型较B基因型易引起患者肝炎慢性化,可能与乙肝病毒C基因型S蛋白的B细胞抗原位点少且抗原指数较低有一定关系.
목적 분석을간병독B기인형화C기인형B세포표위적차이급의의.방법 통과호련망종GenBank수색을HF병독B기인형화C기인형적S단백안기산서렬,사용DANStar생물학연건다개삼수예측B세포항원표위,병재호련망복무기상용Kolaskear-tongaonakar법예측을간병독B기인형화C기인형적S단향적B세포항원위점.결과 종합예측을간병독B기인형화C기인형S단백적B세포항원위점,B기인형적S단백유5개B세포항원위점,C기섬형적S단백유3개B세포항원위점,병차B기인형적B세포항원위점적종합항원지수(1.0798)고우C기인형적B세포항원위점적종합항원지수(1.0729).결론 간염병독C기인형교B기인형역인기환자간염만성화,가능여을간병독C기인형S단백적B세포항원위점소차항원지수교저유일정관계.
Objective To study the difference and sense of B cell epitope of S protein HBV genotype B and genotype C. Methods Search for amino acid sequence of S protein of HBV genotype C and genotype B from GcnBank for international network and forecast B cell epitope of S protein of HBV genotype band genotype C by DNAStar Bio-software and by Kolaskear-tongaonaka method through the international network. Results There are five B cell epitopes about amino acid of S protein of HBV genotype B and three HBV genotype C and antigenic index (1. 0798) of amino acid of S protein of HBV genotype B is higher than that of HBV genotype C (1. 0729). Conclusion Human hepatitis B genotype C is easier to develop chronic hepatitis than that of Human hepatitis B genotype B, It may be related with the fact that there arc fewer B cell epitopes and lower antigenic index about S protein in hu-man hepatitis B genotype C than that in human hepatitis B genotype B.