时珍国医国药
時珍國醫國藥
시진국의국약
LISHIZHEN MEDICINE AND MATERIA MEDICA RESEARCH
2010年
3期
559-561
,共3页
梁贤栋%朱喜英%胡宗仁%常晓铁%刘龙民
樑賢棟%硃喜英%鬍宗仁%常曉鐵%劉龍民
량현동%주희영%호종인%상효철%류룡민
益肾平肝方%阴虚阳亢%高血压%动态血压%血管内皮
益腎平肝方%陰虛暘亢%高血壓%動態血壓%血管內皮
익신평간방%음허양항%고혈압%동태혈압%혈관내피
Yishen Pinggan Decoction%Yinxu-Yangkang%Hypertension%Ambulatory blood pressure%Vascular endothelial
目的 观察益肾平肝方对阴虚阳亢型高血压病人动态血压及血管内皮功能的影响.方法 收集高血压早期肾损害患者90例,随机分为3组,中药组(益肾平肝方),中西药结合组(益肾平肝方+洛汀新),西药组(洛汀新),用药3个月,观测治疗前后的24 h动态血压、血清内皮素(ET)及一氧化氮(NO)的变化.结果 中药组治疗后动态血压各指标与治疗前比较均有显著下降(P＜0.01或P＜0.05);3组组间比较各指标无显著差异;中药组治疗前后ET、NO两指标有显著差异(P＜0.01),中药组、中西药结合组与西药组组间比较差异显著(P＜0.01).结论 益肾平肝方可有效降低原发性高血压患者的白昼和夜间血压,并在一定程度上可改善和逆转异常的血压昼夜节律;该药的降压作用可能是通过影响血管内皮功能实现的.
目的 觀察益腎平肝方對陰虛暘亢型高血壓病人動態血壓及血管內皮功能的影響.方法 收集高血壓早期腎損害患者90例,隨機分為3組,中藥組(益腎平肝方),中西藥結閤組(益腎平肝方+洛汀新),西藥組(洛汀新),用藥3箇月,觀測治療前後的24 h動態血壓、血清內皮素(ET)及一氧化氮(NO)的變化.結果 中藥組治療後動態血壓各指標與治療前比較均有顯著下降(P＜0.01或P＜0.05);3組組間比較各指標無顯著差異;中藥組治療前後ET、NO兩指標有顯著差異(P＜0.01),中藥組、中西藥結閤組與西藥組組間比較差異顯著(P＜0.01).結論 益腎平肝方可有效降低原髮性高血壓患者的白晝和夜間血壓,併在一定程度上可改善和逆轉異常的血壓晝夜節律;該藥的降壓作用可能是通過影響血管內皮功能實現的.
목적 관찰익신평간방대음허양항형고혈압병인동태혈압급혈관내피공능적영향.방법 수집고혈압조기신손해환자90례,수궤분위3조,중약조(익신평간방),중서약결합조(익신평간방+락정신),서약조(락정신),용약3개월,관측치료전후적24 h동태혈압、혈청내피소(ET)급일양화담(NO)적변화.결과 중약조치료후동태혈압각지표여치료전비교균유현저하강(P＜0.01혹P＜0.05);3조조간비교각지표무현저차이;중약조치료전후ET、NO량지표유현저차이(P＜0.01),중약조、중서약결합조여서약조조간비교차이현저(P＜0.01).결론 익신평간방가유효강저원발성고혈압환자적백주화야간혈압,병재일정정도상가개선화역전이상적혈압주야절률;해약적강압작용가능시통과영향혈관내피공능실현적.
Objective To observe the effects of Yishen Pinggan Decoction on ambulatory blood pressure and vascular endothelial function of Yinxu-Yangkang hypertensive patients.Methods 90 cases of hypertensive patients with early renal damage were randomly divided into 3 groups, Chinese medicine group (Yishen Pinggan Decoction), Chinese medicine plus western group (Yishen Pinggan Decoction + Lotensin), taking western medicine group (Lotensin) medicine for three months, and 24h ambulatory blood pressure, serum ET and NO were observed before and after treatment.Results After treatment, the each indicators of ambulatory blood pressure of Chinese medicine group were significantly decreased compared with those before treatment(P<0.01 of P<0.05).There were no significant difference among three sets of inter-group comparison; Before and after treatment, the levels of ET and NO were different significantly in Chinese medicine group (P<0.01). There was significant difference armong Chinese medicine group andwestern effect and Chinese medicine group combined with western medicine group (P<0.01).Conclusion Yishen Pinggan Decoction is effective in patients with essential hypertension to reduce the daytime and nighttime blood pressure, and improve and reverse the abnormal circadian rhythm of blood pressure to some extent. Hypotensive effect of the decoction may due to the regulation for vascular endothelial function.
