CAJ | 학술논문

目的:探讨神经母细胞瘤(NB)细胞增殖活性在NB恶性程度和预后判断中的价值.方法;应用免疫组化法对20例NB标本中增殖细胞核抗原(PCNA)表达进行检测.结果:PCNA表达指数(PEI)与肿瘤重量、有丝分裂核碎裂指数(MKI)呈正相关,r分别为0.664和0.903;与术后生存时间呈负相关,r=-0.919;年龄＜1岁、临床早期(Ⅰ、Ⅱ期)及ⅣS期、神经节神经母细胞瘤(GNB)、Shimada病理分型F型及肿瘤切除者,其PEI均低于相应组别,P值分别为＞0.05、＜0.05、＜0.05、＜0.01、＜0.05.结论:PCNA的表达与NB的恶性增殖、生长及浸润密切相关,是NB细胞增殖活性增高的分子标志,PEI对判断NB的恶性程度和预后具有重要价值.
목적:탐토신경모세포류(NB)세포증식활성재NB악성정도화예후판단중적개치.방법;응용면역조화법대20례NB표본중증식세포핵항원(PCNA)표체진행검측.결과:PCNA표체지수(PEI)여종류중량、유사분렬핵쇄렬지수(MKI)정정상관,r분별위0.664화0.903;여술후생존시간정부상관,r=-0.919;년령＜1세、림상조기(Ⅰ、Ⅱ기)급ⅣS기、신경절신경모세포류(GNB)、Shimada병리분형F형급종류절제자,기PEI균저우상응조별,P치분별위＞0.05、＜0.05、＜0.05、＜0.01、＜0.05.결론:PCNA적표체여NB적악성증식、생장급침윤밀절상관,시NB세포증식활성증고적분자표지,PEI대판단NB적악성정도화예후구유중요개치.
Objective:To investigate proliferating activity that may help understand the biologic behavior and prognosis of neuroblastoma(NB).Methods;Proliferating cell nuclear antigen (PCNA)of 20 specimens of NB were examined by immunohistochemistry stain.Results:There were positive correlation among PCNA expression index(PEI)and tumor's weight,and mitotic karyorrbexis index(MKI.r=0.664,0.903)and negative correlation between PEI and timing of survival(r=-0.919).In cases under 1 years of age with GNB in early staging,total resection and favorable histopathologic type,the PEIs were significantly lower(P＞0.05,＜0.05,＜0.05,＜0.01,＜0.05,respectively).Conclusions:PCNA is a molecular marker of proliferating activity in NB.PEI may be useful to evaluate the biologic behavior and prognosis of NB.