中华消化杂志
中華消化雜誌
중화소화잡지
Chinese Journal of Digestion
2009年
2期
79-81
,共3页
杨莉%肖英莲%胡品津%陈昊湖%林金坤
楊莉%肖英蓮%鬍品津%陳昊湖%林金坤
양리%초영련%호품진%진호호%림금곤
胃酸%质子泵抑制剂%药物剂量计算
胃痠%質子泵抑製劑%藥物劑量計算
위산%질자빙억제제%약물제량계산
Gastric acid%Proton pump inhibitors%Drug dosage calculations
目的:观察不同剂量埃索美拉唑对健康志愿者胃内pH值的影响.方法:研究为随机、开放、三交叉设计试验,入选的15名健康志愿者分别按3种剂量口服埃索美拉唑[每日1次每次20 mg(A剂量)、每日1次每次40 mg(B剂量)、每日2次每次20 mg(C剂量)],每种剂量连续口服5d,第5天时进行24 h胃内pH值监测.结果:按A、B、C三种剂量口服埃索美拉唑5 d后,24 h胃内pH值>4的时间分别为(18.70±4.19)、(19.27 4±2.68)、(21.16±2.45)h.其中C剂量与其余2种用法比较,差异均有统计学意义(P值均<0.05),其余2种用法间比较差异无统计学意义(P>0.05).C剂量埃索美拉唑用药后胃内全天和夜间的中位pH值及胃内pH值>3、4、5的时时间百分比(全天:6.73±0.64、95.0%±7.5%、92.0%4±10.6%、86.7%±14.5%;夜间:6.22±1.30、93.2%±13.1%、87.8%±20.3%、78.6%±28.9%)与A剂量(全天:5.99±1.83、85.1%±16.3%、81.1%±18.1%、71.5%±20.3%;夜间:4.90±2.14、72.9%±30.5%、67.2%±31.9%、55.7%±31.8%)和B剂量(全天:6.33±0.62、87.9%±9.5%、83.5%±11.7%、75.6%±15.5%;夜间:4.93±1.60、75.7%±20.8%、66.9%±23.8%、53.3%±30.3%)这2种用法比较,差异均有统计学意义(P值均<0.05),后2种用法间比较差异均无统计学意义(P值均>0.05).结论:埃索美拉唑具有较强的抑酸作用,每日2次每次20 mg的剂量抑酸效果优于每日1次每次20 mg和每日1次每次40 mg,后2种方法抑酸效果相似.
目的:觀察不同劑量埃索美拉唑對健康誌願者胃內pH值的影響.方法:研究為隨機、開放、三交扠設計試驗,入選的15名健康誌願者分彆按3種劑量口服埃索美拉唑[每日1次每次20 mg(A劑量)、每日1次每次40 mg(B劑量)、每日2次每次20 mg(C劑量)],每種劑量連續口服5d,第5天時進行24 h胃內pH值鑑測.結果:按A、B、C三種劑量口服埃索美拉唑5 d後,24 h胃內pH值>4的時間分彆為(18.70±4.19)、(19.27 4±2.68)、(21.16±2.45)h.其中C劑量與其餘2種用法比較,差異均有統計學意義(P值均<0.05),其餘2種用法間比較差異無統計學意義(P>0.05).C劑量埃索美拉唑用藥後胃內全天和夜間的中位pH值及胃內pH值>3、4、5的時時間百分比(全天:6.73±0.64、95.0%±7.5%、92.0%4±10.6%、86.7%±14.5%;夜間:6.22±1.30、93.2%±13.1%、87.8%±20.3%、78.6%±28.9%)與A劑量(全天:5.99±1.83、85.1%±16.3%、81.1%±18.1%、71.5%±20.3%;夜間:4.90±2.14、72.9%±30.5%、67.2%±31.9%、55.7%±31.8%)和B劑量(全天:6.33±0.62、87.9%±9.5%、83.5%±11.7%、75.6%±15.5%;夜間:4.93±1.60、75.7%±20.8%、66.9%±23.8%、53.3%±30.3%)這2種用法比較,差異均有統計學意義(P值均<0.05),後2種用法間比較差異均無統計學意義(P值均>0.05).結論:埃索美拉唑具有較彊的抑痠作用,每日2次每次20 mg的劑量抑痠效果優于每日1次每次20 mg和每日1次每次40 mg,後2種方法抑痠效果相似.
목적:관찰불동제량애색미랍서대건강지원자위내pH치적영향.방법:연구위수궤、개방、삼교차설계시험,입선적15명건강지원자분별안3충제량구복애색미랍서[매일1차매차20 mg(A제량)、매일1차매차40 mg(B제량)、매일2차매차20 mg(C제량)],매충제량련속구복5d,제5천시진행24 h위내pH치감측.결과:안A、B、C삼충제량구복애색미랍서5 d후,24 h위내pH치>4적시간분별위(18.70±4.19)、(19.27 4±2.68)、(21.16±2.45)h.기중C제량여기여2충용법비교,차이균유통계학의의(P치균<0.05),기여2충용법간비교차이무통계학의의(P>0.05).C제량애색미랍서용약후위내전천화야간적중위pH치급위내pH치>3、4、5적시시간백분비(전천:6.73±0.64、95.0%±7.5%、92.0%4±10.6%、86.7%±14.5%;야간:6.22±1.30、93.2%±13.1%、87.8%±20.3%、78.6%±28.9%)여A제량(전천:5.99±1.83、85.1%±16.3%、81.1%±18.1%、71.5%±20.3%;야간:4.90±2.14、72.9%±30.5%、67.2%±31.9%、55.7%±31.8%)화B제량(전천:6.33±0.62、87.9%±9.5%、83.5%±11.7%、75.6%±15.5%;야간:4.93±1.60、75.7%±20.8%、66.9%±23.8%、53.3%±30.3%)저2충용법비교,차이균유통계학의의(P치균<0.05),후2충용법간비교차이균무통계학의의(P치균>0.05).결론:애색미랍서구유교강적억산작용,매일2차매차20 mg적제량억산효과우우매일1차매차20 mg화매일1차매차40 mg,후2충방법억산효과상사.
Objective To evaluate the effect of csomeprazole with different dosage and usage regimes on intragastric pH of healthy volunteers. Methods It was a randomized, open-label, three-way crossover study. Fifteen healthy volunteers received esomeprazole with 3 different dosages (20 mg or 40 mg once daily or 20 mg twice daily) with 5 days each. Twenty-four continuous ambulatory intragastric pH was recorded at day 5 of each regime. Results The mean time of intragastric pH above 4 was higher in regime of 20 mg twice daily [(21.16 ±2.45) hours ] than that in regimes of 20 mg once daily [(18. 70±4.19) hours] and 40 mg once daily [(19.27±2.68 ) hours] (P<0.05). The percentages of the sleeping and active period that pH remained above 3,4,5 were significantly higher in regime of 20 mg twice daily(day time:95.0%±7.5% ,92.0%±10.6% ,86.7% ± 14.5% ;night time:93.2%± 13.1% ,87.8%±20.3% ,78.6%±28. 9 % )compared with regimes of 40 mg once daily(day time:87.9%±9.5% ,83.5%±11.7%,75.6%±15.50%, night time:75. 7%±20. 8%,66. 9%±23. 8%,53. 3%±30. 3%) and 20 mg once daily(day time: 85.1 % ± 16.3 %, 81.1 %± 18. 1%, 71.5 % ± 20.3 % ; night time: 72.9 % ± 30.5 %,67.2 % ± 31.9 %, 55.7 % ± 31.8 % ) (P< 0.05 ). Esomeprazole maintained intragastric pH above these pH thresholds for a similar propotion of sleeping and active periods with 40 mg once daily and 20 mg once daily.Conclusions Esomeprazole has strong inhibitory effect on intragastric acid. The regime of 20 mg twice daily is superior to 40 mg once daily and 20 mg once daily in both day and night time acid inhibition.There is no difference between esomeprazole 40 mg once daily and 20 mg once daily.
