CAJ | 학술논문

目的:观察冠心病患者血清载脂蛋白AI(ApoAI)、载脂蛋白B(ApoB)与血浆D-二聚体(DD)水平的变化特点,并探讨它们之间的关系.方法:对124例CHD患者和26例正常人采用免疫散射比浊法测定ApoAI、ApoB浓度,ELISA法测定DD水平.结果:不同类型的冠心病患者中,其DD水平和Apo浓度有所不同(F=44.2,126.3,29.6,P均＜0.01),其中急性心肌梗死(AMI)和不稳定性心绞痛(UAP)组患者ApoB浓度、DD水平均显著高于对照组(P＜0.01);陈旧性心肌梗死(OMI)和稳定性心绞痛(SAP)组患者ApoB浓度高于对照组,ApoAI浓度低于对照组(P＜0.01),但DD水平无改变(P＞0.05).124例冠心病患者相关分析显示:ApoB与DD呈显著正相关,ApoAI与DD呈显著负相关(P＜0.001).结论:冠心病患者存在载脂蛋白代谢异常,AMI、UAP组患者DD水平增高,且载脂蛋白与DD水平有密切关系.
목적:관찰관심병환자혈청재지단백AI(ApoAI)、재지단백B(ApoB)여혈장D-이취체(DD)수평적변화특점,병탐토타문지간적관계.방법:대124례CHD환자화26례정상인채용면역산사비탁법측정ApoAI、ApoB농도,ELISA법측정DD수평.결과:불동류형적관심병환자중,기DD수평화Apo농도유소불동(F=44.2,126.3,29.6,P균＜0.01),기중급성심기경사(AMI)화불은정성심교통(UAP)조환자ApoB농도、DD수평균현저고우대조조(P＜0.01);진구성심기경사(OMI)화은정성심교통(SAP)조환자ApoB농도고우대조조,ApoAI농도저우대조조(P＜0.01),단DD수평무개변(P＞0.05).124례관심병환자상관분석현시:ApoB여DD정현저정상관,ApoAI여DD정현저부상관(P＜0.001).결론:관심병환자존재재지단백대사이상,AMI、UAP조환자DD수평증고,차재지단백여DD수평유밀절관계.
AIM: To evaluate the changes of apolipoprotein AI(ApoAI), apolipoprotein B (ApoB) and D-dimer(DD) in patients with coronary heart disease(CHD),and to explore their relationship.METHODS: ApoAI, ApoB and DD were detected respectively by immunoturbidimetry and ELISA in 124 patients with CHD and 26 normal subjects.RESULTS: Among the patients with CHD,the concentration of ApoB and DD ( F=44.2, 126. 3 and 29.6, P ＜ 0. 01) in those with acute myocardial infarction(AMI) and unstable angina pectoris(UAP) was significantly higher than that of controls( P ＜ 0. 01 ) ,while the concentration of ApoAI was lower than that of controls( P ＜ 0. 01 ). In the subjects with old myocardial infarction and stable angina pectoris, the concentration of ApoB was higher than those of controls ,while ApoAI was lower( P ＜ 0. 01 ). The level of DD had no significant difference compared with that of controls( P ＞ 0. 05). The correlation analysis of 124 patients with CHD showed that ApoB level correlated positively with that of DD, while ApoAI level correlated negatively with DD level( P ＜ 0.001).CONCLUSION: Dyslipidemia exists in patients with CHD and higher DD level can be seen in the AMI and UAP groups. There is a close relationship between apolipoprotein and DD level.