安徽医药
安徽醫藥
안휘의약
ANHUI MEDICAL AND PHARMACEUTICAL JOURNAL
2009年
7期
746-747
,共2页
王和协%董帮兴%刘红%汪玉萍%林国红
王和協%董幫興%劉紅%汪玉萍%林國紅
왕화협%동방흥%류홍%왕옥평%림국홍
依托红霉素颗粒%含量测定%探讨
依託紅黴素顆粒%含量測定%探討
의탁홍매소과립%함량측정%탐토
erythromycin estolate granules%determination%discussion
目的 采用紫外分光光度法测定依托红霉素颗粒中红霉素的含量.方法 根据红霉素在酸性条件下水解后,水解产物在482 nm波长处有最大吸收的特点,对依托红霉素颗粒进行紫外分光光度法测定,并与微生物法测定方法 比较.结果 本法平均回收率为99.9%,RSD为0.6%(n=5);样品含量测定结果 与微生物法比较,无显著性差异(P>0.05).结论 本法缩短了检验周期,快速,适用于该制剂的快速含量测定.
目的 採用紫外分光光度法測定依託紅黴素顆粒中紅黴素的含量.方法 根據紅黴素在痠性條件下水解後,水解產物在482 nm波長處有最大吸收的特點,對依託紅黴素顆粒進行紫外分光光度法測定,併與微生物法測定方法 比較.結果 本法平均迴收率為99.9%,RSD為0.6%(n=5);樣品含量測定結果 與微生物法比較,無顯著性差異(P>0.05).結論 本法縮短瞭檢驗週期,快速,適用于該製劑的快速含量測定.
목적 채용자외분광광도법측정의탁홍매소과립중홍매소적함량.방법 근거홍매소재산성조건하수해후,수해산물재482 nm파장처유최대흡수적특점,대의탁홍매소과립진행자외분광광도법측정,병여미생물법측정방법 비교.결과 본법평균회수솔위99.9%,RSD위0.6%(n=5);양품함량측정결과 여미생물법비교,무현저성차이(P>0.05).결론 본법축단료검험주기,쾌속,괄용우해제제적쾌속함량측정.
Aim To determine erythromycin estolate granules by wring ultraviolet spectrophotometric method.Method Based on the fact that after acidic condition hydrolisis,the hydrolysate has the biggest absorption characteristic at the 482 nm wavelength,estolats granwles were determined by erythromycin ultraviolet spectrophotometric method,and was compared with the microorganism law determination method.Result This average recovery rate was 99.9%.RSD was 0.6%(n=5).There is no significant difference between the two methods(P>0.05).Conclusion This method reduced the examination cycle.It in fast,and suitable for defermination.
