CAJ | 학술논문

为了整合前人的研究,进行综合判断,从循证医学角度对硒与GPx关系进行再认识.本研究通过检索多个数据库及相关资源,利用Meta分析的统计方法,将前人具有共同研究目的相互独立的多个研究结果合并、定量分析,剖析各研究间的差异特征.Meta分析结果表明,对照组与试验组之间鸡肝组织GPx活性差异显著(P＜0.01),硒与GPx活性正相关.但Meta分析结果同时也指出,过去的研究中存在夸大或低估硒对GPx活性作用的事实,本研究中在日粮硒0.2 nag·kg~(-1)水平时,试验组鸡肝组织GPx活性比对照组提高26.79μg·mg~(-1)左右是具有统计学意义的.经典研究方法在鉴别硒与GPx关系方面所得出的结果总的倾向是可信的,但是具体到相关程度的研究则显得不够精确,甚至相互矛盾,这种历史现象也正反映了Meta分析的必要性,也与Meta分析在当今国际兽医学发展中的未来前景符合.
위료정합전인적연구,진행종합판단,종순증의학각도대서여GPx관계진행재인식.본연구통과검색다개수거고급상관자원,이용Meta분석적통계방법,장전인구유공동연구목적상호독립적다개연구결과합병、정량분석,부석각연구간적차이특정.Meta분석결과표명,대조조여시험조지간계간조직GPx활성차이현저(P＜0.01),서여GPx활성정상관.단Meta분석결과동시야지출,과거적연구중존재과대혹저고서대GPx활성작용적사실,본연구중재일량서0.2 nag·kg~(-1)수평시,시험조계간조직GPx활성비대조조제고26.79μg·mg~(-1)좌우시구유통계학의의적.경전연구방법재감별서여GPx관계방면소득출적결과총적경향시가신적,단시구체도상관정도적연구칙현득불구정학,심지상호모순,저충역사현상야정반영료Meta분석적필요성,야여Meta분석재당금국제수의학발전중적미래전경부합.
This study was intended to combine previous results of different independent researches and judge them integrally to re-new our knowledge of the co-relationship between selenium and the activity of GPx from the aspect of evidence-based medicine. A Meta-analysis was facilitated,by searching multi-databases and related resources, and performed by combining and quantitative previous multi-results of different independent researches. The different characteristics of each research were checked. The results of Meta-analysis showed that there was a significant difference of GPx activity in chicks' hepatic tissue between experimental and control groups (P＜0.01)and there was a positive co-relationship between seleniumand the activity of GPx. But the result of Meta-analysis also indicated that there were the facts that the effect of selenium on GPx activity had been overestimated or underestimated in the past, and an extra 26.79 μg·mg~(-1) of GPx activity in comparison with control group in chick's hepatic tissue had statistic importance when 0.mg·kg~(-1) selenium was supplied in diets. The results of the co-relationship between selenium and the activity of GPx generated by classical methods were credible, while it was unprecious to predict the degree of the co-relationship and contrary to each other sometime. This historical phenomena just right reflected the necessary of Meta-analysis and this is in keeping with the development of veterinary medicine.