CAJ | 학술논문

目的探讨经直肠能量多普勒超声(PDUS)定量参数与前列腺结节血管生成的相关性.方法应用PDUS和彩色血流分析软件,记录73例患者共94个前列腺结节的峰值血流指数(PVI).前列腺结节穿刺标本行CD34抗体染色,记录微血管密度(MVD),分析其与PVI的相关性.结果移行区和周围区恶性结节组PVI、MVD均高于良性组(P＜0.05);PVI和MVD在恶性结节组呈正相关(r移行区＝0.76;r周围区＝0.79),移行区良性结节组无相关性(r=0.18),周围区良性结节组有相关性(r=0.44).PVI鉴别移行区结节良恶性的敏感性和特异性分别为78.57%和80.77%,鉴别周围区结节良恶性的敏感性和特异性分别为62.07%和91.00%.结论 PDUS定量参数PVI能间接反映前列腺结节内血管生成的特征,为前列腺结节良恶性的鉴别提供了新的方法.
목적 탐토경직장능량다보륵초성(PDUS)정량삼수여전렬선결절혈관생성적상관성.방법 응용PDUS화채색혈류분석연건,기록73례환자공94개전렬선결절적봉치혈류지수(PVI).전렬선결절천자표본행CD34항체염색,기록미혈관밀도(MVD),분석기여PVI적상관성.결과 이행구화주위구악성결절조PVI、MVD균고우량성조(P＜0.05);PVI화MVD재악성결절조정정상관(r이행구＝0.76;r주위구＝0.79),이행구량성결절조무상관성(r=0.18),주위구량성결절조유상관성(r=0.44).PVI감별이행구결절량악성적민감성화특이성분별위78.57%화80.77%,감별주위구결절량악성적민감성화특이성분별위62.07%화91.00%.결론 PDUS정량삼수PVI능간접반영전렬선결절내혈관생성적특정,위전렬선결절량악성적감별제공료신적방법.
Objective To explore the relationship between the quantitative parameter in transrectal power Doppler ultrasonography (PDUS) and angiogenesis of prostate nodules in pathology. Methods PDUS and the analytic software of color flow were used, and peak vascularization indexs (PVIs) of 94 prostate nodules in 73 patients were recorded. The biopsy specimen was stained with CD34 antibody, and the microvessel density (MVD) was calculated. The correlation between PVI and MVD was statistically analyzed. Results PVI and MVD of the malignant nodules, in both transition zone (TZ) and peripheral zone (PZ), were significantly higher than those of the benign nodules, respectively (P＜0.05). There was positive correlation between PVI and MVD of the malignant nodules (rTZ=0.76;rPZ=0.79), but no correlation between PVI and MVD was found in TZ of benign nodules (r=0.18), while there was correlation between PVI and MVD in PZ (r=0.44). In TZ, the sensitivity and speciality of differentiation malignant nodules from benign nodules were 78.57% and 80.77%, respectively, and in PZ they were 62.07% and 91.00%, respectively. Conclusion As a quantitative parameter in PDUS, PVI can indirectly reflect the angiogenesis of prostate cancerous nodules, providing a new method for differentiation malignant nodules from benign nodules.