CAJ | 학술논문

目的观察小剂量氯胺酮(静脉麻醉药)与中剂量戊巴比妥(镇静、催眠药)对幼猪心内直视手术的复合麻醉效果.方法幼猪30例,肌注氯胺酮3 mg·kg~(-1)和戊巴比妥20 mg·kg~(-1)诱导插管;分别静注氯胺酮、戊巴比妥钠、咪达唑仑、哌库溴铵5,6～8,0.1～0.2,0.1 mg·kg~(-1)·h~(-1),维持麻醉,转机后停用戊巴比妥;记录各期生命体征、血流动力学和动脉血气分析参数等指标的变化.结果 30例于各期血流动力学稳定,麻醉诱导和麻醉维持时间分别为(9±2),(179±15)min;2例分别在诱导期和拔管后,出现呼吸心跳骤停,均抢救成功;诱导和维持效果达I级者分别占73.3%和80.0%.结论小剂量氯胺酮和中剂量戊巴比妥有利于改善呼吸和循环抑制,联合用药兼备镇静和镇痛效果,可达到很好地外科麻醉效果.
목적 관찰소제량록알동(정맥마취약)여중제량무파비타(진정、최면약)대유저심내직시수술적복합마취효과.방법 유저30례,기주록알동3 mg·kg~(-1)화무파비타20 mg·kg~(-1)유도삽관;분별정주록알동、무파비타납、미체서륜、고고추안5,6～8,0.1～0.2,0.1 mg·kg~(-1)·h~(-1),유지마취,전궤후정용무파비타;기록각기생명체정、혈류동역학화동맥혈기분석삼수등지표적변화.결과 30례우각기혈류동역학은정,마취유도화마취유지시간분별위(9±2),(179±15)min;2례분별재유도기화발관후,출현호흡심도취정,균창구성공;유도화유지효과체I급자분별점73.3%화80.0%.결론 소제량록알동화중제량무파비타유리우개선호흡화순배억제,연합용약겸비진정화진통효과,가체도흔호지외과마취효과.
Objective To investigate combination anesthesia with low-dose ketamine and mid-dose pentobarbital for open heart surgery in ju-venile pigs.Methods Thirty experimental juvenile pigs received ket-amine(3 mg·kg~(-1))and pentobarbital(20 mg·kg~(-1))intramuscularly for induction and intubation,then were given ketamine(5 mg·kg~(-1)·h~(-1)),pentobarbital(6-8 mg·kg~(-1)·h~(-1)),midazolam(0.1-0.2mg kg~(-1)·h~(-1))and pipecuronium(0.1 mg·kg~(-1)·h~(-1))intravenously for maintenance.The infusion of pentobarbital was withdrawn after car-diopulmonary bypass started.During the experimental treatment,vital signs were monitored;artery gas analysis and hemodynamie parameters were recorded.Results Twenty-eight juvenile pigs got stable hemody-namic parameters in the perioperative period.The time of anesthetic in-duction and maintenance is(9±2)and(179±15)min,respectively.The respiratory and cardiac arrest rates were 6.7% in induction and 3.3% in maintenance.respectively.Two cases got respiratory and cardi-ac arrest.on in induction and the OtIler after extubation.In addition,class I anesthetic effectiveness was achieved 73.3% in induction and 80.0% in maintenance,respectively.Conclusion This study demon-strated that lOW-dose ketamine combined with mid-dose pentobarbihal has little inhibition on respiration and circulation.The combination can achieve both hypnosis and analgesia effects with good surgical anesthetic effectiveness in juvenile pigs with open heart surgery.